ArticleBiochemical and biophysical research communications2008
Molluscan mobile elements similar to the vertebrate Recombination-Activating Genes.
Article in Biochemical and biophysical research communications, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Immunity: defense against infections essential for all living organisms.Frontiers in immunology · 2026Review
- Structural insights into the evolution of the RAG recombinase.Nature reviews. Immunology · 2022Review
- The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination.The Journal of experimental medicine · 2021Article
- Guardian of the Genome: An Alternative RAG/Transib Co-Evolution Hypothesis for the Origin of V(D)J Recombination.Frontiers in immunology · 2021Article
- The Tc1-like elements with the spliceosomal introns in mollusk genomes.Molecular genetics and genomics : MGG · 2020Article
- Functional requirement of terminal inverted repeats for efficientNational science review · 2020Article
- New insights into the genome repetitive fraction of the Antarctic bivalve Adamussium colbecki.PloS one · 2018Article
- New insights into the evolutionary origins of the recombination-activating gene proteins and V(D)J recombination.The FEBS journal · 2017Review
- The RAG transposon is active through the deuterostome evolution and domesticated in jawed vertebrates.Immunogenetics · 2017Article
- Whole genome analysis of a schistosomiasis-transmitting freshwater snail.Nature communications · 2017Article
- Article
- Evolution of adaptive immunity from transposable elements combined with innate immune systems.Nature reviews. Genetics · 2015Review
- PGBD5: a neural-specific intron-containing piggyBac transposase domesticated over 500 million years ago and conserved from cephalochordates to humans.Mobile DNA · 2013Article
- Gene flow and biological conflict systems in the origin and evolution of eukaryotes.Frontiers in cellular and infection microbiology · 2012Article
- Horizontal gene transfers with or without cell fusions in all categories of the living matter.Advances in experimental medicine and biology · 2011Review
- Construction of a medicinal leech transcriptome database and its application to the identification of leech homologs of neural and innate immune genes.BMC genomics · 2010Article
- The origins of the Rag genes--from transposition to V(D)J recombination.Seminars in immunology · 2010Review
- Integrating prokaryotes and eukaryotes: DNA transposases in light of structure.Critical reviews in biochemistry and molecular biology · 2010Review
- New superfamilies of eukaryotic DNA transposons and their internal divisions.Molecular biology and evolution · 2009Article
- Molluscan memory of injury: evolutionary insights into chronic pain and neurological disorders.Brain, behavior and evolution · 2009Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Animal genomes contain approximately 20,000 genes. Additionally millions of genes for antigen receptors are generated in cells of the immune system from the sets of separate gene segments by a mechanism known as the V(D)J somatic recombination. The components of the V(D)J recombination system, Recombination-Activating Gene proteins (RAG1 and RAG2) and recombination signal sequence (RSS), are thought to have "entered" the vertebrate genome as a hypothetical "RAG transposon". Recently discovered mobile elements have terminal inverted repeats (TIRs) similar to RSS and may encode proteins with a different degree of similarity to RAG1. We describe a novel N-RAG-TP transposon identified from the sea slug Aplysia californica that encodes a protein similar to the N-terminal part of RAG1 in vertebrates. This refines the "RAG transposon" hypothesis and allows us to propose a scenario for V(D)J recombination machinery evolution from a relic transposon related to the existing mobile elements N-RAG-TP, Chapaev, and Transib.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.