ArticleProceedings of the National Academy of Sciences of the United States of America1991
Modeling the cell division cycle: cdc2 and cyclin interactions.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers.
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Who cites it
134 citing papers in PubMed.
- Are physiological oscillations physiological?The Journal of physiology · 2026Review
- Revisiting Turing's Chemical Basis of Morphogenesis.Bulletin of mathematical biology · 2026Review
- Synthetic Cell-Based Approaches to Dissect Autonomous Cellular Oscillators: Recent Applications on the Cell Cycle.Advances in experimental medicine and biology · 2026Review
- Physical Frameworks and Theories on How Autonomous Biological Oscillators Synchronize.Advances in experimental medicine and biology · 2026Review
- Mechanistic modeling of cell viability assays with in silico lineage tracing.PLoS computational biology · 2025Article
- From sampling to simulating: Single-cell multiomics in systems pathophysiological modeling.iScience · 2024Review
- Curating models from BioModels: Developing a workflow for creating OMEX files.bioRxiv : the preprint server for biology · 2024Article
- Cell Cycle Complexity: Exploring the Structure of Persistent Subsystems in 414 Models.Biomedicines · 2024Article
- Selenium catalysis enables negative feedback organic oscillators.Nature communications · 2024Article
- Design patterns of biological cells.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024Review
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- A model of replicating coupled oscillators generates naturally occurring cell networks.Development (Cambridge, England) · 2023Article
- Computing all persistent subspaces of a reaction-diffusion system.Scientific reports · 2023Article
- GillesPy2: A Biochemical Modeling Framework for Simulation Driven Biological Discovery.Letters in biomathematics · 2023Article
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- Improving dynamic predictions with ensembles of observable models.Bioinformatics (Oxford, England) · 2023Article
- Learning in Transcriptional Network Models: Computational Discovery of Pathway-Level Memory and Effective Interventions.International journal of molecular sciences · 2022Article
- Network design principle for robust oscillatory behaviors with respect to biological noise.eLife · 2022Article
- Quantitative models for building and growing fated small cell networks.Interface focus · 2022Review
74 more citing papers are in PubMed but not listed here.
Corrections and comments
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1 author.
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Abstract
The proteins cdc2 and cyclin form a heterodimer (maturation promoting factor) that controls the major events of the cell cycle. A mathematical model for the interactions of cdc2 and cyclin is constructed. Simulation and analysis of the model show that the control system can operate in three modes: as a steady state with high maturation promoting factor activity, as a spontaneous oscillator, or as an excitable switch. We associate the steady state with metaphase arrest in unfertilized eggs, the spontaneous oscillations with rapid division cycles in early embryos, and the excitable switch with growth-controlled division cycles typical of nonembryonic cells.
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