ArticleBMC evolutionary biology2008
X-chromosome SNP analyses in 11 human Mediterranean populations show a high overall genetic homogeneity except in North-west Africans (Moroccans).
Article in BMC evolutionary biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 45 citations in OpenAlex.
- Article
- Exploring the Western Mediterranean through X-chromosome.International journal of legal medicine · 2021Article
- Alternatives to amelogenin markers for sex determination in humans and their forensic relevance.Molecular biology reports · 2020Review
- A single nucleotide polymorphism panel for individual identification and ancestry assignment in Caucasians and four East and Southeast Asian populations using a machine learning classifier.Forensic science, medicine, and pathology · 2019Article
- Genetic Differentiation of North-East Argentina Populations Based on 30 Binary X Chromosome Markers.Frontiers in genetics · 2018Article
- Potential forensic use of a 33 X-InDel panel in the Argentinean population.International journal of legal medicine · 2017Review
- Genetic analysis of 12 X-chromosome STRs in Western Mediterranean populations.International journal of legal medicine · 2015Article
- The peopling of Greenland: further insights from the analysis of genetic diversity using autosomal and X-chromosomal markers.European journal of human genetics : EJHG · 2015Article
- Article
- A method for the analysis of 32 X chromosome insertion deletion polymorphisms in a single PCR.International journal of legal medicine · 2012Article
- Human genetic differentiation across the Strait of Gibraltar.BMC evolutionary biology · 2010Article
- Analysis of 21 X-chromosomal STRs in an Algerian population sample.International journal of legal medicine · 2010Article
- The Mediterranean Sea as a barrier to gene flow: evidence from variation in and around the F7 and F12 genomic regions.BMC evolutionary biology · 2010Article
- Article
- Mitochondrial DNA haplogroup H structure in North Africa.BMC genetics · 2009Article
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDue to its history, with a high number of migration events, the Mediterranean basin represents a challenging area for population genetic studies. A large number of genetic studies have been carried out in the Mediterranean area using different markers but no consensus has been reached on the genetic landscape of the Mediterranean populations. In order to further investigate the genetics of the human Mediterranean populations, we typed 894 individuals from 11 Mediterranean populations with 25 single-nucleotide polymorphisms (SNPs) located on the X-chromosome.
resultsA high overall homogeneity was found among the Mediterranean populations except for the population from Morocco, which seemed to differ genetically from the rest of the populations in the Mediterranean area. A very low genetic distance was found between populations in the Middle East and most of the western part of the Mediterranean Sea.A higher migration rate in females versus males was observed by comparing data from X-chromosome, mt-DNA and Y-chromosome SNPs both in the Mediterranean and a wider geographic area.Multilocus association was observed among the 25 SNPs on the X-chromosome in the populations from Ibiza and Cosenza.
conclusionOur results support both the hypothesis of (1) a reduced impact of the Neolithic Wave and more recent migration movements in NW-Africa, and (2) the importance of the Strait of Gibraltar as a geographic barrier. In contrast, the high genetic homogeneity observed in the Mediterranean area could be interpreted as the result of the Neolithic wave caused by a large demic diffusion and/or more recent migration events. A differentiated contribution of males and females to the genetic landscape of the Mediterranean area was observed with a higher migration rate in females than in males. A certain level of background linkage disequilibrium in populations in Ibiza and Cosenza could be attributed to their demographic background.
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