ArticleCritical care (London, England)2008
Acute lung injury and the acute respiratory distress syndrome in Ireland: a prospective audit of epidemiology and management.
Article in Critical care (London, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05101694 (Study on the Correlation Between Alveolar Macrophage-derived Autophagosomes and the Severity of Lung Injury in ARDS), which is not on this map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study on the Correlation Between Alveolar Macrophage-derived Autophagosomes and the Severity of Lung Injury in ARDS
Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Tidal volume and plateau pressure use for acute lung injury from 2000 to present: a systematic literature review.Critical care medicine · 2014Pooled it
- APACHE III Outcome Prediction in Patients Admitted to the Intensive Care Unit with Sepsis Associated Acute Lung Injury.PloS one · 2015Trial
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- Glucocorticoid therapy for acute respiratory distress syndrome: Current concepts.Journal of intensive medicine · 2024Review
- Management of severe acute respiratory distress syndrome in Australia and New Zealand (SAGE-ANZ): An observational study.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2024Article
- The Epidemiology of Acute Respiratory Distress Syndrome Before and After Coronavirus Disease 2019.Critical care clinics · 2021Review
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- Risk of Acute Respiratory Distress Syndrome Among Older Adults Living Near Construction and Manufacturing Sites.Epidemiology (Cambridge, Mass.) · 2020Article
- Impact of Long-Term Exposures to Ambient PMChest · 2019Observational
- Allicin Improves Lung Injury Induced by Sepsis via Regulation of the Toll-Like Receptor 4 (TLR4)/Myeloid Differentiation Primary Response 88 (MYD88)/Nuclear Factor kappa B (NF-κB) Pathway.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- G994T polymorphism in exon 9 of plasma platelet-activating factor acetylhydrolase gene and lung ultrasound score as prognostic markers in evaluating the outcome of acute respiratory distress syndrome.Experimental and therapeutic medicine · 2019Article
- Hypoxemia in the ICU: prevalence, treatment, and outcome.Annals of intensive care · 2018Article
- Definition and epidemiology of acute respiratory distress syndrome.Annals of translational medicine · 2017Review
- Epidemiological analysis of 9,596 patients with acute lung injury at Chinese Military Hospitals.Experimental and therapeutic medicine · 2017Article
- National survey of outcomes and practices in acute respiratory distress syndrome in Singapore.PloS one · 2017Observational
- Incidence and recognition of acute respiratory distress syndrome in a UK intensive care unit.Thorax · 2016Article
- Activation of Coagulation and Fibrinolysis in Acute Respiratory Distress Syndrome: A Prospective Pilot Study.Frontiers in medicine · 2016Article
- Fluid strategies and outcomes in patients with acute respiratory distress syndrome, systemic inflammatory response syndrome and sepsis: a protocol for a systematic review and meta-analysis.Systematic reviews · 2015Article
- Inhaled carbon monoxide protects time-dependently from loss of hypoxic pulmonary vasoconstriction in endotoxemic mice.Respiratory research · 2015Article
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1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe aim of this study was to describe the epidemiology and management of acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) in Ireland.
methodsAs part of a 10-week prospective national audit of patient demographics and organ failure incidence in intensive care in Ireland, all patients with ALI/ARDS in 14 participating centres were prospectively identified using American European Consensus Conference definitions.
resultsThere were 1,029 admissions during the study period; of these, 728 patients were invasively ventilated. A total of 196 (19%) patients had ALI/ARDS, and 141 of these (72%) had ALI/ARDS on admission and a further 55 (28%) developed ALI/ARDS after admission. For the patients with ALI/ARDS, the mean (+/- standard deviation) age was 58 +/- 17 years and 62% were male. The most common predisposing risk factors were pneumonia (50%) and nonpulmonary sepsis (26%). Mean (+/- standard deviation) tidal volume/kg was 7.0 +/- 1.7 ml/kg. Median (interquartile range) duration of ventilation was 6.8 (2.0 to 12.8) days. Median (interquartile range) length of stay in the intensive care unit was 10.0 (5.0 to 18.5) days. The overall intensive care unit mortality for ALI/ARDS was 32.3%. Lower baseline arterial oxygen tension/fraction of inspired oxygen ratio and higher Sequential Organ Failure Assessment scores were associated with increased mortality. Although not significant, patients receiving treatment with a statin during admission had a 73% lower odds of death (odds ratio 0.27, 95% confidence interval 0.06 to 1.21; P = 0.09).
conclusionThe incidence of ALI/ARDS is high and is associated with significant mortality. Protective lung ventilation is used commonly throughout participating centres. With low tidal volume ventilation, the degree of hypoxaemia is associated with outcome. These data will inform future multicentre clinical trials in ALI/ARDS in Ireland.
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