ArticleBMC medical genetics2008
Role of TGF-beta1 haplotypes in the occurrence of myocardial infarction in young Italian patients.
Article in BMC medical genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Pooled it
- TGFB1 genetic polymorphisms and coronary heart disease risk: a meta-analysis.BMC medical genetics · 2012Pooled it
- Meta-analysis of the association between transforming growth factor-beta polymorphisms and complications of coronary heart disease.PloS one · 2012Pooled it
- Interleukin-10 and Transforming Growth Factor Beta1 Gene Polymorphisms in Chronic Heart Failure.Acta bio-medica : Atenei Parmensis · 2019Article
- Rutin inhibits coronary heart disease through ERK1/2 and Akt signaling in a porcine model.Experimental and therapeutic medicine · 2018Article
- Article
- Article
- A novel association between TGFb1 and ADAMTS4 in coronary artery disease: A new potential mechanism in the progression of atherosclerosis and diabetes.Anatolian journal of cardiology · 2015Article
- Article
- Transforming growth factor beta1 gene variation Leu10Pro affects secretion and function in hepatic cells.Digestive diseases and sciences · 2012Article
- Interaction between smoking and functional polymorphism in the TGFB1 gene is associated with ischaemic heart disease and myocardial infarction in patients with rheumatoid arthritis: a cross-sectional study.Arthritis research & therapy · 2012Article
- Contribution of the TGFB1 Gene to Myocardial Infarction Susceptibility.Acta naturae · 2012Article
- Association of transforming growth factor-β1 gene C-509T and T869C polymorphisms with atherosclerotic cerebral infarction in the Chinese: a case-control study.Lipids in health and disease · 2011Article
- Association between transforming growth factor beta1 polymorphisms and atrial fibrillation in essential hypertensive subjects.Journal of biomedical science · 2010Article
- Association between transforming growth factor beta1 polymorphisms and left ventricle hypertrophy in essential hypertensive subjects.Molecular and cellular biochemistry · 2010Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTransforming growth factor beta 1 (TGF-beta1) gene play an important role in the acute myocardial infarction (AMI), however no investigation has been conducted so far in young AMI patients. In this study, we evaluated the influence of TGF-beta1 polymorphisms/haplotypes on the onset and progression of AMI in young Italian population.
methods201 cases and 201 controls were genotyped for three TGF-beta1 polymorphisms (G-800A, C-509T and Leu10Pro). The main follow-up end-points (mean follow-up, 107 +/- 49 months) were death, myocardial infarction or revascularization procedures.
resultsSignificant risk factors were smoking (p < 10-4), family history for coronary artery disease (p < 10-4), hypercholesterolemia (p = 0.001) and hypertension (p = 0.002). The C-509T and Leu10Pro polymorphisms showed significant differences (p = 0.026 and p = 0.004) between cases and controls. The most common haplotypes revealed a possible protective effect (GCT, OR 0.75, 95% CI 0.57-0.99, p = 0.042) and an increased risk of AMI (GTC, OR 1.51, 95% CI 1.13-2.02, p = 0.005), respectively. No statistical differences were observed in genotype distribution in the follow-up study between the two groups: 61 patients with subsequent events (13 deaths) and 108 without events.
conclusionEven though our results need to be further confirmed in larger studies, this is the first study reporting on a possible role of TGFbeta1 common haplotypes in the onset of AMI in young patients.
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