Trial reportJournal of the American Geriatrics Society2008
Inflammatory biomarkers and physical function in older, obese adults with knee pain and self-reported osteoarthritis after intensive weight-loss therapy.
Trial report in Journal of the American Geriatrics Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 5 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- The effect of dietary weight-loss interventions on the inflammatory markers interleukin-6 and TNF-alpha in adults with obesity: A systematic review and meta-analysis of randomized controlled clinical trials.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis.Arthritis research & therapy · 2024Pooled it
- Adults with excess weight or obesity, but not with overweight, report greater pain intensities than individuals with normal weight: a systematic review and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Weight Loss Interventions in Older Adults with Obesity: A Systematic Review of Randomized Controlled Trials Since 2005.Journal of the American Geriatrics Society · 2017Pooled it
- A systematic review of behavioural techniques used in nutrition and weight loss interventions among adults with mobility-impairing neurological and musculoskeletal conditions.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2014Pooled it
- A long-term intensive lifestyle intervention and physical function: the look AHEAD Movement and Memory Study.Obesity (Silver Spring, Md.) · 2015Trial
- A combination of Scutellaria baicalensis and Acacia catechu extracts for short-term symptomatic relief of joint discomfort associated with osteoarthritis of the knee.Journal of medicinal food · 2014Trial
- Influence of weight loss, body composition, and lifestyle behaviors on plasma adipokines: a randomized weight loss trial in older men and women with symptomatic knee osteoarthritis.Journal of obesity · 2012Trial
- Correlation between serum pro inflammatory cytokines and clinical scores of knee osteoarthritic patients using resveratrol as a supplementary therapy with meloxicam.Indian journal of pharmacologyTrial
- Joint Pain and Leisure-Time Physical Activity: Cross-Sectional Findings From the Cardiovascular Health Study.Health science reports · 2025Article
- Article
- Effects of Pomegranate (Punica granatum L.) Peel Extract Supplementation on Markers of Inflammation and Serum Matrix Metalloproteinase 1 in Women With Knee Osteoarthritis: A Randomized Double-Blind Placebo-Controlled Study.Nutrition and metabolic insights · 2024Article
- Dietary total antioxidant capacity is associated with lower disease severity and inflammatory and oxidative stress biomarkers in patients with knee osteoarthritis.Journal of health, population, and nutrition · 2023Article
- The effects of a 6-month weight loss intervention on physical function and serum biomarkers in older adults with and without osteoarthritis.Osteoarthritis and cartilage open · 2023Article
- Protocol for the POMELO (Prevention Of MusclE Loss in Osteoarthritis) randomized pilot feasibility trial.Osteoarthritis and cartilage open · 2022Article
- Serum and Synovial Fluid Levels of Interleukin-17A in Primary Knee Osteoarthritis Patients: Correlations With Functional Status, Pain, and Disease Severity.Archives of rheumatology · 2022Article
- Review
- C-reactive protein rise in response to macronutrient deficit early in critical illness: sign of inflammation or mediator of infection prevention and recovery.Intensive care medicine · 2022Article
- Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise.International journal of environmental research and public health · 2021Review
- Poor health-related physical fitness performance increases the overweight and obesity risk in older adults from Taiwan.BMC geriatrics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo describe the relationships between proinflammatory biomarkers and self-reported and performance-based physical function and to examine the effect of weight loss on these markers of inflammation.
designRandomized, longitudinal, clinical study comparing subjects eating an energy-restricted diet and participating in exercise training with a control group.
settingCommunity-base participants for the Physical Activity, Inflammation and Body Composition Trial.
participantsEighty-seven obese (body mass index (BMI) >30.0 kg/m(2)) adults aged 60 and older with knee pain and self-report of osteoarthritis. MEASUREMENTS: Inflammatory biomarkers (interleukin 6 (IL-6), tumor necrosis factor alpha (TNFalpha), C-reactive protein, and soluble receptors for TNFalpha (sTNFR1 and sTNFR2)) and self-reported (Western Ontario and McMaster University Osteoarthritis Index questionnaire) and performance-based (6-minute walk distance and stair climb time) measures of physical function at baseline and 6 months.
resultsMean (standard error of the mean) weight loss was 8.7% (0.8%) in the intervention group, compared with 0.0% (0.7%) in the control group. sTNFR1 was significantly less in the intervention group than in the control group at 6 months. sTNFR1 and sTNFR2 predicted stair climb time at baseline. Change across the 6-month intervention for sTNFR2 was an independent predictor for change in 6-minute walk distance.
conclusionThese results indicate that an intensive weight-loss intervention in older obese adults with knee pain can help improve inflammatory biomarkers and that changes in these concentrations showed associations with physical function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.