ArticleJournal of proteome research2008
Application of protein microarrays for multiplexed detection of antibodies to tumor antigens in breast cancer.
Article in Journal of proteome research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
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Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 145 citations in OpenAlex.
- A systematic review of humoral immune responses against tumor antigens.Cancer immunology, immunotherapy : CII · 2009Pooled it
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- Identification of Antibody Targets for Tuberculosis Serology using High-Density Nucleic Acid Programmable Protein Arrays.Molecular & cellular proteomics : MCP · 2017Article
- Recognition of tumor antigens in 4T1 cells by natural IgM from three strains of mice with different susceptibilities to spontaneous breast cancer.Oncology letters · 2017Article
- Identification of Novel and Noninvasive Biomarkers of Acute Cellular Rejection After Liver Transplantation by Protein Microarray.Transplantation direct · 2016Article
- Application of flat panel OLED display technology for the point-of-care detection of circulating cancer biomarkers.Scientific reports · 2016Article
- Proteomic mapping of p53 immunogenicity in pancreatic, ovarian, and breast cancers.Proteomics. Clinical applications · 2016Article
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- Proteomic Monitoring of B Cell Immunity.Methods in molecular biology (Clifton, N.J.) · 2016Article
- Protein array identification of protein markers for serodiagnosis of Mycobacterium tuberculosis infection.Scientific reports · 2015Article
- Natural and adaptive IgM antibodies in the recognition of tumor-associated antigens of breast cancer (Review).Oncology reports · 2015Review
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Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
There is strong preclinical evidence that cancer, including breast cancer, undergoes immune surveillance. This continual monitoring, by both the innate and the adaptive immune systems, recognizes changes in protein expression, mutation, folding, glycosylation, and degradation. Local immune responses to tumor antigens are amplified in draining lymph nodes, and then enter the systemic circulation. The antibody response to tumor antigens, such as p53 protein, are robust, stable, and easily detected in serum; may exist in greater concentrations than their cognate antigens; and are potential highly specific biomarkers for cancer. However, antibodies have limited sensitivities as single analytes, and differences in protein purification and assay characteristics have limited their clinical application. For example, p53 autoantibodies in the sera are highly specific for cancer patients, but are only detected in the sera of 10-20% of patients with breast cancer. Detection of p53 autoantibodies is dependent on tumor burden, p53 mutation, rapidly decreases with effective therapy, but is relatively independent of breast cancer subtype. Although antibodies to hundreds of other tumor antigens have been identified in the sera of breast cancer patients, very little is known about the specificity and clinical impact of the antibody immune repertoire to breast cancer. Recent advances in proteomic technologies have the potential for rapid identification of immune response signatures for breast cancer diagnosis and monitoring. We have adapted programmable protein microarrays for the specific detection of autoantibodies in breast cancer. Here, we present the first demonstration of the application of programmable protein microarray ELISAs for the rapid identification of breast cancer autoantibodies.
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