ArticleJournal of clinical immunology2008
Human CD8 responses to a complete epitope set from preproinsulin: implications for approaches to epitope discovery.
Article in Journal of clinical immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Granzymes in health and diseases: the good, the bad and the ugly.Frontiers in immunology · 2024Review
- A Single L/D-Substitution at Q4 of the mInsAFrontiers in immunology · 2021Article
- Adoptive Transfer of mRNA-Transfected T Cells Redirected against Diabetogenic CD8 T Cells Can Prevent Diabetes.Molecular therapy : the journal of the American Society of Gene Therapy · 2017Article
- CD8 T cell autoreactivity to preproinsulin epitopes with very low human leucocyte antigen class I binding affinity.Clinical and experimental immunology · 2012Article
- Etiopathogenesis of insulin autoimmunity.Anatomy research international · 2012Article
- Viruses and cytotoxic T lymphocytes in type 1 diabetes.Clinical reviews in allergy & immunology · 2011Review
- Deficiency in B7-H1 (PD-L1)/PD-1 coinhibition triggers pancreatic beta-cell destruction by insulin-specific, murine CD8 T-cells.Diabetes · 2010Article
- Toxin-coupled MHC class I tetramers can specifically ablate autoreactive CD8+ T cells and delay diabetes in nonobese diabetic mice.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma.The Journal of clinical investigation · 2009Article
- Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.Laboratory investigation; a journal of technical methods and pathology · 2009Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeIn this study, we explored the breadth of CD8 T cell reactivity to preproinsulin (PPI) in type 1 diabetes. MATERIALS AND
methodsWe tested a complete peptide set in pools covering all 406 potential 8-11mer epitopes of PPI and 61 algorithm-predicted human leukocyte antigen (HLA)-A2-specific epitopes (15 pools) from islet-specific glucose-6-phophatase catalytic subunit-related protein (IGRP), using a CD8-specific granzyme B enzyme-linked immunosorbent spot assay.
resultsResponses were seen to 64 of the 102 PPI pools in two or more newly diagnosed patients (63%) compared to 11 pools in the control subjects (11%, p < 0.0001, Fisher's exact test). We identified five pools containing 20 peptides, which distinguished patients from control subjects, most of which had predicted low-affinity binding to HLA class I molecules. In contrast, fewer (5 of 15 = 33%) IGRP peptide pools, selected by higher binding affinity for HLA-A2 (present in seven of eight patients and five of seven control subjects), stimulated responses in two or more patients, and none stimulated responses in more than two control subjects (p = 0.042, Fisher's exact test).
conclusionThus, we conclude that CD8 T cell reactivity to PPI in patients with type 1 diabetes can be much broader than shown previously and more diverse than seen in control subjects. Furthermore, responses were often stimulated by peptides with low predicted HLA-binding affinities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.