SynthesisWorld journal of surgery2008
Evidence-based assessment of the role of ultrasonography in the management of benign thyroid nodules.
Synthesis in World journal of surgery, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Use of the Kwak Thyroid Image Reporting and Data System (K-TIRADS) in differential diagnosis of thyroid nodules: systematic review and meta-analysis.European radiology · 2018Pooled it
- Thyroid imaging reporting and data system (TI-RADS) in the diagnostic value of thyroid nodules: a systematic review.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- German Association of Endocrine Surgeons practice guidelines for the surgical treatment of benign thyroid disease.Langenbeck's archives of surgery · 2011Guideline
- Review
- Incidence of Injury to External Branch of Superior Laryngeal Nerve as Diagnosed by Acoustic Voice Analysis After Thyroidectomy.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- Ultrasound-On-Chip With Semiconductor Silicon Chip Array for Transcutaneous Salivary Gland Injections: A Pilot Cadaver Study.Laryngoscope investigative otolaryngology · 2025Article
- Clinical Characteristics and Predictors Related to the Progression of Multinodular Goiter Causing Tracheal Compression and Deviation: A Report of Two Cases and Review of the Literature.Internal medicine (Tokyo, Japan) · 2022Review
- Non-Toxic Multinodular Goiter: From Etiopathogenesis to Treatment.Sisli Etfal Hastanesi tip bulteni · 2022Review
- Comparison of the Pretzelflex Retractor and Nathanson Retractor in Laparoscopic Sleeve Gastrectomy Surgery.Obesity surgery · 2021Article
- Diagnosis of thyroid nodules for ultrasonographic characteristics indicative of malignancy using random forest.BioData mining · 2020Article
- Integration of Sonoelastography Into the TIRADS Lexicon Could Influence the Classification.Frontiers in endocrinology · 2019Article
- Small-Sized Thyroid Cancers-a Single Institutional Experience in India.Indian journal of surgical oncology · 2018Article
- The utility of thyroid ultrasonography in the management of thyroid nodules.Canadian journal of surgery. Journal canadien de chirurgie · 2017Article
- Contrast-enhanced ultrasound and real-time elastography in the differential diagnosis of malignant and benign thyroid nodules.Experimental and therapeutic medicine · 2016Article
- Triage of patients with AUS/FLUS on thyroid cytopathology: effectiveness of the multimodal diagnostic techniques.Cancer medicine · 2016Article
- Well-Differentiated Thyroid Cancer: The Philippine General Hospital Experience.Endocrinology and metabolism (Seoul, Korea) · 2016Article
- German Association of Endocrine Surgeons practice guideline for the surgical management of malignant thyroid tumors.Langenbeck's archives of surgery · 2013Review
- Avoiding unnecessary fine-needle aspiration cytology by accuractely predicting the benign nature of thyroid nodules using ultrasound.Journal of clinical imaging science · 2012Article
- Elevation of liver function tests after laparoscopic gastrectomy using a Nathanson liver retractor.World journal of surgery · 2011Article
- Investigating the value of fine needle aspiration cytology in thyroid cancer.Journal of cytology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough ultrasonographic (US) evaluation is currently recommended for the workup of all palpable thyroid nodules, little guidance exists regarding the manner in which US data are to be used. Herein, we examine the available evidence and recommend how US can be used most effectively to predict malignancy. We discuss the role of US-guided fine needle aspiration (FNA) and other special topics regarding US evaluation and management of benign nodules.
methodsWe also present a systematic review of the literature using evidence-based criteria.
resultsUS features alone cannot predict malignancy or benignity, but techniques that combine US features and FNA cytology are most effective and most accurate for predicting malignancy (Level III and IV evidence). US features suggesting malignancy include a blurred or ill-defined margin, irregular shape, solid echo structure, hypoechogenicity, absent halo, fine calcifications, and intranodular vascular pattern. Most patients with malignancies have more than two US features characteristic of malignancy. US-guided FNA has nonsignificantly higher sensitivity, specificity, and accuracy than the palpation-guided technique (Level III and IV evidence). US guidance is particularly beneficial in patients with nonpalpable, multiple, or heterogeneous nodules for preferentially aspirating a specific segment of the nodule (large or partially cystic nodule) or when nodule palpation is difficult (patients with diffuse glandular disease or obesity).
conclusionsUS is an essential component of thyroid nodule evaluation and management. Techniques that combine US features and FNA cytology for thyroid nodule workup are more accurate than either technique alone. US-guided FNA can decrease the rate of nondiagnostic aspirates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.