ArticlePharmaceutical research2008
Mechanistic analysis of chemical permeation enhancers for oral drug delivery.
Article in Pharmaceutical research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 68 citations in OpenAlex.
- About the impact of medium chain fatty acids on the permeation enhancing effects of self-emulsifying drug delivery systems.Drug delivery and translational research · 2026Article
- Investigation of Transdermal Drug Delivery and In Vivo Pharmacokinetics of Choline Ketoprofen Ionic Liquid.ACS materials Au · 2026Article
- Modification of Peptide and Permeation Enhancer In Vitro Release Rates by Dispersion with a Gel-Forming Polymer.Pharmaceutical research · 2025Article
- Gastrointestinal Permeation Enhancers Beyond Sodium Caprate and SNAC - What is Coming Next?Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- A Pseudo-Surfactant Chemical Permeation Enhancer to Treat Otitis Media via Sustained Transtympanic Delivery of Antibiotics.Advanced healthcare materials · 2024Article
- Long-term daily oral administration of intestinal permeation enhancers is safe and effective in mice.Bioengineering & translational medicine · 2023Article
- Characterization technique of gases permeation properties in polymers: HScientific reports · 2022Article
- The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications.International journal of molecular sciences · 2020Review
- Advances in oral peptide therapeutics.Nature reviews. Drug discovery · 2020Review
- Thrifty, Rapid Intestinal Monolayers (TRIM) Using Caco-2 Epithelial Cells for Oral Drug Delivery Experiments.Pharmaceutical research · 2019Article
- Non-invasive delivery strategies for biologics.Nature reviews. Drug discovery · 2019Review
- Impact of SodiumMolecules (Basel, Switzerland) · 2018Article
- Ionic liquids for addressing unmet needs in healthcare.Bioengineering & translational medicine · 2018Review
- An Assessment of the Permeation Enhancer, 1-phenyl-piperazine (PPZ), on Paracellular Flux Across Rat Intestinal Mucosae in Ussing Chambers.Pharmaceutical research · 2016Article
- Development of enoxaparin sodium polymeric microparticles for colon-specific delivery.Clujul medical (1957) · 2015Article
- Efficacious intestinal permeation enhancement induced by the sodium salt of 10-undecylenic acid, a medium chain fatty acid derivative.The AAPS journal · 2014Article
- Physicomechanical characterization and optimization of EDTA-mPEG and Avicel®-EDTA-mPEG in situ melt dispersion mini-pellets.AAPS PharmSciTech · 2013Article
- Zanamivir oral delivery: enhanced plasma and lung bioavailability in rats.Biomolecules & therapeutics · 2013Article
- Needle-shaped polymeric particles induce transient disruption of cell membranes.Journal of the Royal Society, Interface · 2010Article
- DNA vaccines for targeting bacterial infections.Expert review of vaccines · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTraditionally, the oral route cannot be employed for the delivery of macromolecular drugs such as proteins and peptides due, in large part, to limited transport across the epithelial membrane. This particular challenge can potentially be addressed through the use of chemical permeation enhancers, which affect transcellular and/or paracellular transport routes. Although certain permeation enhancers have been proposed for use in oral delivery, potential for application is often unclear when the route of enhancer action is unknown.
methodsA combination of theory and experiments was developed for determining mechanism of enhancer action. The effect of 51 enhancers on Caco-2 cells was studied using TEER, MTT, and LDH assays.
resultsThe mechanistic details of intestinal permeability enhancement were uncovered for a broad set of enhancers in vitro. Understanding gained from enhancer mechanisms enabled the deduction of structure-function relationships for hydrophilic and hydrophobic permeation enhancers as well as the identification of a transcellular enhancer, 0.01% (w/v) palmityldimethyl ammonio propane sulfonate, which enabled the non-cytotoxic intracellular delivery of a model drug.
conclusionsThe results presented here emphasize the importance of understanding enhancer mechanism and uncover a zwitterionic surfactant capable of safely and effectively achieving intraepithelial drug delivery in vitro.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.