ReviewBritish journal of pharmacology2008
Asthma from a pharmacogenomic point of view.
Review in British journal of pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Association of GAB1 gene with asthma susceptibility and the efficacy of inhaled corticosteroids in children.BMC pulmonary medicine · 2023Article
- Gene expression data analysis identifies multiple deregulated pathways in patients with asthma.Bioscience reports · 2018Article
- Article
- Different anti-apoptotic effects of normal and asthmatic serum on normal eosinophil apoptosis depending on house dust mite-specific IgE.Molecular biology reports · 2013Article
- Asthma treatment outcome in children is associated with vascular endothelial growth factor A (VEGFA) polymorphisms.Molecular diagnosis & therapy · 2012Article
- Association of house dust mite-specific IgE with asthma control, medications and household pets.Asia Pacific allergy · 2011Article
- Differences in candidate gene association between European ancestry and African American asthmatic children.PloS one · 2011Article
- Pharmacogenetics of asthma in children.Allergy, asthma & immunology research · 2010Article
- Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children.PLoS genetics · 2009Article
- Arginase enzymes in isolated airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin.Toxicology and applied pharmacology · 2009Article
- Similarities and differences in the autonomic control of airway and urinary bladder smooth muscle.Naunyn-Schmiedeberg's archives of pharmacology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pharmacogenomics, a fascinating, emerging area of biomedical research is strongly influenced by growing availability of genomic databases, high-throughput genomic technologies, bioinformatic tools and artificial computational modelling approaches. One main area of pharmacogenomics is the discovery of new drugs and drug targets with molecular genetic, genomic or even bioinformatic methods; the other is the study of how genomic differences influence the variability in patients' responses to drugs. From a genetic point of view, asthma is multifactorial, which means that the susceptibility to the disease is determined by interactions between multiple genes, and involves important non-genetic factors such as the environment for their expression. In this review, we summarize collective evidence from linkage and association studies that have consistently reported suggestive linkage or association of asthma or its associated phenotypes to polymorphic markers and single nucleotide polymorphisms in selected chromosomes. Genes that have been found implicated in the disease are potential new drug targets and several pharmacological investigations are underway to utilize these new discoveries. Next, we will focus on the inter-individual variability in anti-asthmatic drug responses and review the recent results in this topic.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.