ArticleNature neuroscience2008
TrkB kinase is required for recovery, but not loss, of cortical responses following monocular deprivation.
Article in Nature neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.
- Is criticality a unified setpoint of brain function?Neuron · 2025Pooled it
- From Regeneration Failure to Functional Restoration: Unlocking the Neuronal-Intrinsic Regenerative Capacity as a Therapeutic Frontier for Optic Neuropathy and Glaucoma.CNS neuroscience & therapeutics · 2026Review
- Single-cell sequencing reveals reversible glial remodeling in the visual cortex during visual deprivation and recovery.Frontiers in immunology · 2026Article
- Integration of Transplanted Interneurons Over a New Period of Ocular Dominance Plasticity in Adult Visual Cortex.bioRxiv : the preprint server for biology · 2025Article
- Neurotrophin NT-4/5 Promotes Structural Changes in Neurons of the Developing Visual Cortex.bioRxiv : the preprint server for biology · 2023Article
- Experience dependent plasticity of higher visual cortical areas in the mouse.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Dendrites help mitigate the plasticity-stability dilemma.Scientific reports · 2023Article
- Experience-dependent functional plasticity and visual response selectivity of surviving subplate neurons in the mouse visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Production of brain-derived neurotrophic factor gates plasticity in developing visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- A requirement for astrocyte IPFrontiers in cellular neuroscience · 2022Article
- Homeostatic mechanisms regulate distinct aspects of cortical circuit dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Silent Synapse-Based Mechanisms of Critical Period Plasticity.Frontiers in cellular neuroscience · 2020Review
- Experience-dependent structural plasticity at pre- and postsynaptic sites of layer 2/3 cells in developing visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- The antidepressant fluoxetine acts on energy balance and leptin sensitivity via BDNF.Scientific reports · 2018Article
- Monocular deprivation induces dendritic spine elimination in the developing mouse visual cortex.Scientific reports · 2017Article
- Enhancement of visual cortex plasticity by dark exposure.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Homeostatic plasticity mechanisms in mouse V1.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Changes in visual cortical responses that are induced by monocular visual deprivation are a widely studied example of competitive, experience-dependent neural plasticity. It has been thought that the deprived-eye pathway will fail to compete against the open-eye pathway for limited amounts of brain-derived neurotrophic factor, which acts on TrkB and is needed to sustain effective synaptic connections. We tested this model by using a chemical-genetic approach in mice to inhibit TrkB kinase activity rapidly and specifically during the induction of cortical plasticity in vivo. Contrary to the model, TrkB kinase activity was not required for any of the effects of monocular deprivation. When the deprived eye was re-opened during the critical period, cortical responses to it recovered. This recovery was blocked by TrkB inhibition. These findings suggest a more conventional trophic role for TrkB signaling in the enhancement of responses or growth of new connections, rather than a role in competition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.