ArticleNature chemical biology2008
Progressive ordering with decreasing temperature of the phospholipids of influenza virus.
Article in Nature chemical biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers.
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Who cites it
124 citing papers in PubMed, 234 citations in OpenAlex.
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- Prediction of influenza-like illness incidence using meteorological factors in Kunming : deep learning model study.BMC public health · 2025Article
- Trends and factors influencing over-the-counter cold and cough medication sales in Guangzhou, China: 2011-2017.BMC infectious diseases · 2025Article
- How virus migration and meteorological elements shape the seasonality of influenza a/H3N2: A case study in China.One health (Amsterdam, Netherlands) · 2025Article
- National spatiotemporal patterns of influenza-like illness in Iran: A pre-COVID-19 study (2015-2019).PloS one · 2025Article
- Impact of multiple environmental factors on influenza-like illness in Fujian Province, China, 2015-2023: a multicity study.Frontiers in public health · 2025Article
- Frequency-aligned loss and spectral filtering improve long-range influenza forecasting.Frontiers in public health · 2025Article
- Impact of meteorological factors on transmission of respiratory viruses across all age groups in the hot arid climate in Qatar.Frontiers in public health · 2025Article
- Meteorological factors, population immunity, and COVID-19 incidence: A global multi-city analysis.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Effect of short-term ambient temperature exposure on influenza A and B incidence: a time-series analysis of daily surveillance data in Kawasaki City, Japan.IJID regions · 2024Article
- Stabilization of an Infectious Enveloped Virus by Spray-Drying and Lyophilization.Journal of pharmaceutical sciences · 2024Article
- Forecasting of influenza activity and associated hospital admission burden and estimating the impact of COVID-19 pandemic on 2019/20 winter season in Hong Kong.PLoS computational biology · 2024Article
- Does behavior mediate the effect of weather on SARS-CoV-2 transmission? Evidence from cell-phone data.medRxiv : the preprint server for health sciences · 2024Article
- Effects of meteorological factors on influenza transmissibility by virus type/subtype.BMC public health · 2024Article
- Antiviral activity of the host defense peptide piscidin 1: investigating a membrane-mediated mode of action.Frontiers in chemistry · 2024Article
- Does behavior mediate the effect of weather on SARS-CoV-2 transmission? evidence from cell-phone data.PloS one · 2024Article
- The effects of weather and mobility on respiratory viruses dynamics before and during the COVID-19 pandemic in the USA and Canada.PLOS digital health · 2023Article
- Nonlinear and Multidelayed Effects of Meteorological Drivers on Human Respiratory Syncytial Virus Infection in Japan.Viruses · 2023Article
64 more citing papers are in PubMed but not listed here.
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4 authors at 1 institution in 1 country.
Funding
Abstract
Using linewidth and spinning sideband intensities of lipid hydrocarbon chain resonances in proton magic angle spinning NMR spectra, we detected the temperature-dependent phase state of naturally occurring lipids of intact influenza virus without exogenous probes. Increasingly, below 41 degrees C ordered and disordered lipid domains coexisted for the viral envelope and extracts thereof. At 22 degrees C much lipid was in a gel phase, the fraction of which reversibly increased with cholesterol depletion. Diffusion measurements and fluorescence microscopy independently confirmed the existence of gel-phase domains. Thus the existence of ordered regions of lipids in biological membranes is now demonstrated. Above the physiological temperatures of influenza infection, the physical properties of viral envelope lipids, regardless of protein content, were indistinguishable from those of the disordered fraction. Viral fusion appears to be uncorrelated to ordered lipid content. Lipid ordering may contribute to viral stability at lower temperatures, which has recently been found to be critical for airborne transmission.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.