ArticleThe American journal of pathology2008
Trp53 deletion stimulates the formation of metastatic pancreatic tumors.
Article in The American journal of pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- The pancreatic cancer genome revisited.Nature reviews. Gastroenterology & hepatology · 2021Review
- Review
- Chronic inflammation initiates multiple forms of K-Ras-independent mouse pancreatic cancer in the absence of TP53.Oncogene · 2017Article
- PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance.Genes & development · 2016Article
- Activation of WNT/β-Catenin Signaling Enhances Pancreatic Cancer Development and the Malignant Potential Via Up-regulation of Cyr61.Neoplasia (New York, N.Y.) · 2016Article
- p53 and p16Neoplasia (New York, N.Y.) · 2016Article
- Utilizing past and present mouse systems to engineer more relevant pancreatic cancer models.Frontiers in physiology · 2014Review
- Challenges and advances in mouse modeling for human pancreatic tumorigenesis and metastasis.Cancer metastasis reviews · 2013Review
- Study human pancreatic cancer in mice: how close are they?Biochimica et biophysica acta · 2013Review
- Poly(ADP-ribosyl)ation of p53 induces gene-specific transcriptional repression of MTA1.Oncogene · 2012Article
- A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition.The Journal of cell biology · 2011Article
- Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells.PloS one · 2011Article
- Doubles game: Src-Stat3 versus p53-PTEN in cellular migration and invasion.Molecular and cellular biology · 2010Article
- Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- p53 suppresses Src-induced podosome and rosette formation and cellular invasiveness through the upregulation of caldesmon.Molecular and cellular biology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The presence of distant metastases is a common finding on diagnosis of pancreatic cancer; however, the mechanisms underlying the dissemination of this tumor type remain poorly understood. Loss of the p53 tumor suppressor protein has been associated with tumor progression and metastasis in several tumor types including pancreatic ductal adenocarcinoma. Here, we describe the generation of a progressive and metastatic pancreatic cancer mouse model after the somatic and sporadic delivery of avian retroviruses encoding the mouse polyoma virus middle T antigen to elastase-tv-a transgenic mice with a pancreas-specific deletion of the Trp53 tumor suppressor locus. In this model, the tumors metastasize most frequently to the liver, consistent with human pancreatic carcinomas. Analysis of metastatic lesions demonstrated that concomitant loss of the Ink4a/Arf locus was not required for metastasis; however, pancreas-specific deletion of a single Ink4a/Arf allele cooperated with Trp53 deletion in a haploinsufficient manner to accelerate tumor development. Thus, our findings illustrate the potential role of p53 loss of function in pancreatic tumor progression, demonstrate the feasibility of modeling pancreatic cancer metastasis after somatic and sporadic oncogene activation, and indicate that our model may provide a useful experimental system for investigation of the molecular mechanisms underlying pancreatic cancer progression and metastasis.
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Registered trials
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