ArticleLearning & memory (Cold Spring Harbor, N.Y.)2008
Visual pattern memory requires foraging function in the central complex of Drosophila.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- The foraging gene coordinates brain and heart networks to modulate socially cued interval timing in Drosophila.PLoS genetics · 2025Article
- Diversity of visual inputs to Kenyon cells of the Drosophila mushroom body.Nature communications · 2024Article
- Diversity of visual inputs to Kenyon cells of thebioRxiv : the preprint server for biology · 2023Article
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- A Visual Pathway into Central Complex for High-Frequency Motion-Defined Bars inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
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- Family before work: task reversion in workers of the red imported fire ant, Solenopsis invicta in the presence of brood.Scientific reports · 2023Article
- Sleep benefits different stages of memory inFrontiers in physiology · 2023Review
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- A neural circuit linking two sugar sensors regulates satiety-dependent fructose drive inScience advances · 2021Article
- A connectome of theeLife · 2021Article
- TheJournal of neurogenetics · 2021Article
- Expression of theJournal of neurogenetics · 2021Article
- Molecular and neural mechanisms regulating sexual motivation of virgin female Drosophila.Cellular and molecular life sciences : CMLS · 2021Review
- Transsynaptic mapping ofeLife · 2021Article
- AKH Signaling inFrontiers in physiology · 2021Article
- Automated real-time quantification of group locomotor activity in Drosophila melanogaster.Scientific reports · 2019Article
- Inverse Control of Turning Behavior by Dopamine D1 Receptor Signaling in Columnar and Ring Neurons of the Central Complex in Drosophila.Current biology : CB · 2019Article
- Long noncoding RNA SMRG regulates Drosophila macrochaetes by antagonizing scute through E(spl)mβ.RNA biology · 2019Article
- The clock gene period differentially regulates sleep and memory in Drosophila.Neurobiology of learning and memory · 2018Article
Corrections and comments
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The role of the foraging (for) gene, which encodes a cyclic guanosine-3',5'-monophosphate (cGMP)-dependent protein kinase (PKG), in food-search behavior in Drosophila has been intensively studied. However, its functions in other complex behaviors have not been well-characterized. Here, we show experimentally in Drosophila that the for gene is required in the operant visual learning paradigm. Visual pattern memory was normal in a natural variant rover (for(R)) but was impaired in another natural variant sitter (for(S)), which has a lower PKG level. Memory defects in for(S) flies could be rescued by either constitutive or adult-limited expression of for in the fan-shaped body. Interestingly, we showed that such rescue also occurred when for was expressed in the ellipsoid body. Additionally, expression of for in the fifth layer of the fan-shaped body restored sufficient memory for the pattern parameter "elevation" but not for "contour orientation," whereas expression of for in the ellipsoid body restored sufficient memory for both parameters. Our study defines a Drosophila model for further understanding the role of cGMP-PKG signaling in associative learning/memory and the neural circuit underlying this for-dependent visual pattern memory.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.