ArticleThe American journal of sports medicine2008
Response of knee ligaments to prolotherapy in a rat injury model.
Article in The American journal of sports medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Comparing dextrose prolotherapy with other substances in knee osteoarthritis pain relief: A systematic review.Clinics (Sao Paulo, Brazil) · 2022Pooled it
- Efficacy of hypertonic dextrose injection (prolotherapy) in temporomandibular joint dysfunction: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Prolotherapy for Osteoarthritis and Tendinopathy: a Descriptive Review.Current rheumatology reports · 2017Pooled it
- A systematic review of four injection therapies for lateral epicondylosis: prolotherapy, polidocanol, whole blood and platelet-rich plasma.British journal of sports medicine · 2009Pooled it
- Treatment of Osteoarthritis Secondary to Developmental Dysplasia of the Hip with Prolotherapy Injection versus a Supervised Progressive Exercise Control.Medical science monitor : international medical journal of experimental and clinical research · 2020Trial
- Dextrose and morrhuate sodium injections (prolotherapy) for knee osteoarthritis: a prospective open-label trial.Journal of alternative and complementary medicine (New York, N.Y.) · 2014Trial
- Hypertonic dextrose injections (prolotherapy) for knee osteoarthritis: results of a single-arm uncontrolled study with 1-year follow-up.Journal of alternative and complementary medicine (New York, N.Y.) · 2012Trial
- Biopuncture, A Multitarget Therapy in the Treatment of Individuals with Knee Osteoarthritis: state of the art.Journal of pharmacopuncture · 2024Review
- Comparative Efficacy of Intra-Articular Injection, Physical Therapy, and Combined Treatments on Pain, Function, and Sarcopenia Indices in Knee Osteoarthritis: A Network Meta-Analysis of Randomized Controlled Trials.International journal of molecular sciences · 2023Article
- A Case Series: Effect of Comorbidities on the Outcomes of Prolotherapy Injection for Frozen Shoulder Patients.International medical case reports journal · 2023Article
- Article
- Prolotherapy for the patients with chronic musculoskeletal pain: systematic review and meta-analysis.Anesthesia and pain medicine · 2021Article
- Ultrasound-guided dextrose injection treatment for chronic myofascial pain syndrome: A retrospective case series.Journal of the Chinese Medical Association : JCMA · 2020Article
- Conservative Treatment of Chronic Achilles Tendinopathy: A Systematic Review.Journal of functional morphology and kinesiology · 2019Review
- The effectiveness of prolotherapy on failed rotator cuff repair surgery.Turkish journal of physical medicine and rehabilitation · 2019Article
- Analgesic Effect and Potential Cumulative Benefit from Caudal Epidural D5W in Consecutive Participants with Chronic Low-Back and Buttock/Leg Pain.Journal of alternative and complementary medicine (New York, N.Y.) · 2018Article
- Prolotherapy Induces an Inflammatory Response in Human Tenocytes In Vitro.Clinical orthopaedics and related research · 2017Article
- A high-glucose diet affects Achilles tendon healing in rats.Scientific reports · 2017Article
- A Systematic Review of Dextrose Prolotherapy for Chronic Musculoskeletal Pain.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2016Review
- Therapeutic effects of prolotherapy with intra-articular dextrose injection in patients with moderate knee osteoarthritis: a single-arm study with 6 months follow up.Therapeutic advances in musculoskeletal disease · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundProlotherapy is an alternative therapy for chronic musculoskeletal injury including joint laxity. The commonly used injectant, D-glucose (dextrose), is hypothesized to improve ligament mechanics and decrease pain through an inflammatory mechanism. No study has investigated the mechanical effects of prolotherapy on stretch-injured ligaments. HYPOTHESES: Dextrose injections will enlarge cross-sectional area, decrease laxity, strengthen, and stiffen stretch-injured medial collateral ligaments (MCLs) compared with controls. Dextrose prolotherapy will increase collagen fibril diameter and density of stretch-injured MCLs. STUDY
designControlled laboratory study.
methodsTwenty-four rats were bilaterally MCL stretch-injured, and the induced laxity was measured. After 2 weeks, 32 MCLs were injected twice, 1 week apart, with either dextrose or saline control; 16 MCLs received no injection. Seven uninjured rats (14 MCLs) were additional controls. Two weeks after the second injection, ligament laxity, mechanical properties (n = 8), and collagen fibril diameter and density (n = 3) were assessed.
resultsThe injury model created consistent ligament laxity (P < .05) that was not altered by dextrose injections. Cross-sectional area of dextrose-injected MCLs was increased 30% and 90% compared with saline and uninjured controls, respectively (P < .05). Collagen fibril diameter and density were decreased in injured ligaments compared with uninjured controls (P < .05), but collagen fibril characteristics were not different between injured groups.
conclusionDextrose injections increased the cross-sectional area of MCLs compared with saline-injected and uninjured controls. Dextrose injections did not alter other measured properties in this model. CLINICAL RELEVANCE: Our results suggest that clinical improvement from prolotherapy may not result from direct effects on ligament biomechanics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.