ArticleThe Journal of experimental biology2008
A newly identified extrinsic input triggers a distinct gastric mill rhythm via activation of modulatory projection neurons.
Article in The Journal of experimental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 62 citations in OpenAlex.
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- Switching neuron contributions to second network activity.Journal of neurophysiology · 2024Article
- Motor neurons within a network use cell-type specific feedback mechanisms to constrain relationships among ion channel mRNAs.Journal of neurophysiology · 2023Article
- Neural circuit regulation by identified modulatory projection neurons.Frontiers in neuroscience · 2023Review
- Multiple intrinsic membrane properties are modulated in a switch from single- to dual-network activity.Journal of neurophysiology · 2022Article
- Neuromodulation Enables Temperature Robustness and Coupling Between Fast and Slow Oscillator Circuits.Frontiers in cellular neuroscience · 2022Article
- Feeding state-dependent modulation of feeding-related motor patterns.Journal of neurophysiology · 2021Article
- Perturbation-specific responses by two neural circuits generating similar activity patterns.Current biology : CB · 2021Article
- Neuronal Switching between Single- and Dual-Network Activity via Modulation of Intrinsic Membrane Properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Mass Spectrometry Quantification, Localization, and Discovery of Feeding-Related Neuropeptides inACS chemical neuroscience · 2021Article
- Different microcircuit responses to comparable input from one versus both copies of an identified projection neuron.The Journal of experimental biology · 2020Article
- Similarities and differences in circuit responses to applied GlyJournal of neurophysiology · 2019Article
- State-dependent sensorimotor gating in a rhythmic motor system.Journal of neurophysiology · 2017Article
- Circuit feedback increases activity level of a circuit input through interactions with intrinsic properties.Journal of neurophysiology · 2017Article
- Functional consequences of neuropeptide and small-molecule co-transmission.Nature reviews. Neuroscience · 2017Review
- Complicating connectomes: Electrical coupling creates parallel pathways and degenerate circuit mechanisms.Developmental neurobiology · 2017Review
- Neuroendocrine modulation sustains theeLife · 2016Article
- Network feedback regulates motor output across a range of modulatory neuron activity.Journal of neurophysiology · 2016Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Neuronal network flexibility enables animals to respond appropriately to changes in their internal and external states. We are using the isolated crab stomatogastric nervous system to determine how extrinsic inputs contribute to network flexibility. The stomatogastric system includes the well-characterized gastric mill (chewing) and pyloric (filtering of chewed food) motor circuits in the stomatogastric ganglion. Projection neurons with somata in the commissural ganglia (CoGs) regulate these rhythms. Previous work characterized a unique gastric mill rhythm that occurred spontaneously in some preparations, but whose origin remained undetermined. This rhythm includes a distinct protractor phase activity pattern, during which a key gastric mill circuit neuron (LG neuron) and the projection neurons MCN1 and CPN2 fire in a pyloric rhythm-timed activity pattern instead of the tonic firing pattern exhibited by these neurons during previously studied gastric mill rhythms. Here we identify a new extrinsic input, the post-oesophageal commissure (POC) neurons, relatively brief stimulation (30 s) of which triggers a long-lasting (tens of minutes) activation of this novel gastric mill rhythm at least in part via its lasting activation of MCN1 and CPN2. Immunocytochemical and electrophysiological data suggest that the POC neurons excite MCN1 and CPN2 by release of the neuropeptide Cancer borealis tachykinin-related peptide Ia (CabTRP Ia). These data further suggest that the CoG arborization of the POC neurons comprises the previously identified anterior commissural organ (ACO), a CabTRP Ia-containing neurohemal organ. This endocrine organ thus appears to also have paracrine actions, including activation of a novel and lasting gastric mill rhythm.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.