ArticleNucleic acids research2008
Two conserved modules of Schizosaccharomyces pombe Mediator regulate distinct cellular pathways.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Genetic and environmental determinants of multicellular-like phenotypes in fission yeast.Genetics · 2026Article
- A role for condensin-mediator interaction in mitotic chromosome organization.Nature communications · 2026Article
- Unique Role of Med8 in Ace2 Recruitment and Target Gene Expression inJournal of microbiology and biotechnology · 2025Article
- Cyclin-dependent kinases: Masters of the eukaryotic universe.Wiley interdisciplinary reviews. RNA · 2023Review
- Interaction map of Arabidopsis Mediator complex expounding its topology.Nucleic acids research · 2019Article
- Glycan Alteration Imparts Cellular Resistance to a Membrane-Lytic Anticancer Peptide.Cell chemical biology · 2017Article
- Expression of AtMed15 of Arabidopsis in yeast causes flocculation and increases ethanol production in yeast culture.Scientific reports · 2016Article
- Article
- Mediator can regulate mitotic entry and direct periodic transcription in fission yeast.Molecular and cellular biology · 2014Article
- Mediator directs co-transcriptional heterochromatin assembly by RNA interference-dependent and -independent pathways.PLoS genetics · 2013Article
- Article
- Conserved versatile master regulators in signalling pathways in response to stress in plants.AoB PLANTS · 2013Review
- Mediator regulates non-coding RNA transcription at fission yeast centromeres.Epigenetics & chromatin · 2012Article
- Mediator promotes CENP-a incorporation at fission yeast centromeres.Molecular and cellular biology · 2012Article
- Cyclin-dependent kinase 8 regulates mitotic commitment in fission yeast.Molecular and cellular biology · 2012Article
- The functions of Mediator in Candida albicans support a role in shaping species-specific gene expression.PLoS genetics · 2012Article
- Deciphering the transcriptional-regulatory network of flocculation in Schizosaccharomyces pombe.PLoS genetics · 2012Article
- Role for cohesin in the formation of a heterochromatic domain at fission yeast subtelomeres.Molecular and cellular biology · 2011Article
- A chromatin-remodeling protein is a component of fission yeast mediator.The Journal of biological chemistry · 2010Article
- Identification, structure, and functional requirement of the Mediator submodule Med7N/31.The EMBO journal · 2009Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mediator is an evolutionary conserved coregulator complex required for transcription of almost all RNA polymerase II-dependent genes. The Schizosaccharomyces pombe Mediator consists of two dissociable components-a core complex organized into a head and middle domain as well as the Cdk8 regulatory subcomplex. In this work we describe a functional characterization of the S. pombe Mediator. We report the identification of the S. pombe Med20 head subunit and the isolation of ts alleles of the core head subunit encoding med17+. Biochemical analysis of med8(ts), med17(ts), Deltamed18, Deltamed20 and Deltamed27 alleles revealed a stepwise head domain molecular architecture. Phenotypical analysis of Cdk8 and head module alleles including expression profiling classified the Mediator mutant alleles into one of two groups. Cdk8 module mutants flocculate due to overexpression of adhesive cell-surface proteins. Head domain-associated mutants display a hyphal growth phenotype due to defective expression of factors required for cell separation regulated by transcription factor Ace2. Comparison with Saccharomyces cerevisiae Mediator expression data reveals that these functionally distinct modules are conserved between S. pombe and S. cerevisiae.
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