ArticleThe Journal of physiology2008
Substance P depolarizes striatal projection neurons and facilitates their glutamatergic inputs.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Human microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carryingScience advances · 2026Article
- Morphological Changes in Direct Pathway Striatal Neurons in a Rat Model of Tardive Dyskinesia.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Extrinsic and intrinsic control of striatal cholinergic interneuron activity.Frontiers in molecular neuroscience · 2025Review
- Involvement of neuronal tachykinin-like receptor at 86C iniScience · 2023Article
- Decreased plasma neuropeptides in first-episode schizophrenia, bipolar disorder, major depressive disorder: associations with clinical symptoms and cognitive function.Frontiers in psychiatry · 2023Article
- Members of the KCTD family are major regulators of cAMP signaling.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A Multi-Scale Computational Model of Levodopa-Induced Toxicity in Parkinson's Disease.Frontiers in neuroscience · 2022Article
- Synaptic Zinc: An Emerging Player in Parkinson's Disease.International journal of molecular sciences · 2021Review
- Gap Junctions Between Striatal D1 Neurons and Cholinergic Interneurons.Frontiers in cellular neuroscience · 2021Article
- High-Frequency Activation of Nucleus Accumbens D1-MSNs Drives Excitatory Potentiation on D2-MSNs.Neuron · 2019Article
- Long-term plasticity of corticostriatal synapses is modulated by pathway-specific co-release of opioids through κ-opioid receptors.The Journal of physiology · 2017Article
- Intrinsic membrane properties and cholinergic modulation of mouse basal forebrain glutamatergic neurons in vitro.Neuroscience · 2017Article
- Striatal Neuropeptides Enhance Selection and Rejection of Sequential Actions.Frontiers in computational neuroscience · 2017Article
- Generation of a NK1R-CreER knockin mouse strain to study cells involved in Neurokinin 1 Receptor signaling.Genesis (New York, N.Y. : 2000) · 2016Article
- Dual-transmitter neurons: functional implications of co-release and co-transmission.Current opinion in neurobiology · 2014Review
- GABAergic inputs from direct and indirect striatal projection neurons onto cholinergic interneurons in the primate putamen.The Journal of comparative neurology · 2013Article
- Distribution and intrinsic membrane properties of basal forebrain GABAergic and parvalbumin neurons in the mouse.The Journal of comparative neurology · 2013Article
- Heterogeneous properties of central lateral and parafascicular thalamic synapses in the striatum.The Journal of physiology · 2013Article
- Cortical nNOS neurons co-express the NK1 receptor and are depolarized by Substance P in multiple mammalian species.Frontiers in neural circuits · 2012Article
- Opioidergic interactions between striatal projection neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The striatum is the main basal ganglia input nucleus, receiving extensive glutamatergic inputs from cortex and thalamus. Medium spiny striatal projection neurons (MSNs) are GABAergic, and their axon collaterals synapse on other MSNs. Approximately 50% of MSNs corelease substance P (SP), but how this neurotransmitter controls MSN activity is poorly understood. We used whole-cell recordings to investigate how SP affects MSNs and their glutamatergic inputs. SP elicited slow depolarizations in 47/90 MSNs, which persisted in the presence of tetrodotoxin (TTX). SP responses were mimicked by the NK1 receptor agonist [Sar9,Met(O(2))11]-substance P (SSP), and fully blocked by the NK1 receptor antagonists L-732,138, or extracellular zinc. When intracellular chloride was altered, the polarity of SP responses depended on the sign of the chloride driving force. In voltage-clamp, SP-induced currents reversed around -68 mV and displayed marked inward rectification. These data indicate that SP increased a ClC-2-type chloride conductance in MSNs, acting through NK1 receptors. SP also strongly increased glutamatergic responses in 49/89 MSNs. Facilitation of glutamatergic responses (which was observed both in MSNs directly affected by SP and in non-affected ones) was reduced by application of L-732,138, and fully blocked by coapplication of L-732,138 and SB222200 (an NK3 receptor antagonists), showing that both NK1 and NK3 receptors were involved. SP-induced facilitation of glutamatergic responses was accompanied by a marked decrease in paired-pulse ratio, indicating a presynaptic mechanism of action. These data provide an electrophysiological correlate for the anatomically known connections between SP-positive MSN terminals and the dendrites and somata of other MSNs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.