ArticleClinical immunology (Orlando, Fla.)2008
Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections.
Article in Clinical immunology (Orlando, Fla.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- An update on leprosy immunopathogenesis: systematic review.Frontiers in immunology · 2024Pooled it
- The IL-10-producing NKT10 subset plays a critical role in preventing graft-versus-host-disease.Frontiers in immunology · 2026Article
- The gut and lung microbiome across the TB disease spectrum.Frontiers in microbiology · 2025Review
- Microbiota and Immunity during Respiratory Infections: Lung and Gut Affair.International journal of molecular sciences · 2024Review
- Early innate cell interactions withFrontiers in immunology · 2023Review
- A humanized mouse model forFrontiers in immunology · 2022Article
- High Dimensionality Reduction and Immune Phenotyping of Natural Killer and Invariant Natural Killer Cells in Latent Tuberculosis-Diabetes Comorbidity.Journal of immunology research · 2022Article
- The role of donor-unrestricted T-cells, innate lymphoid cells, and NK cells in anti-mycobacterial immunity.Immunological reviews · 2021Review
- In search of biomarkers for leprosy by unraveling the host immune response to Mycobacterium leprae.Immunological reviews · 2021Review
- IL-7 During Antigenic Stimulation Using Allogeneic Dendritic Cells Promotes Expansion of CD45RAFrontiers in immunology · 2020Article
- Harnessing Unconventional T Cells for Immunotherapy of Tuberculosis.Frontiers in immunology · 2020Review
- Mucosal-associated invariant and γδ T cell subsets respond to initial Mycobacterium tuberculosis infection.JCI insight · 2018Article
- A Diverse Lipid Antigen-Specific TCR Repertoire Is Clonally Expanded during Active Tuberculosis.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Article
- Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Lung Infections.Frontiers in immunology · 2018Review
- Quantitative and qualitative iNKT repertoire associations with disease susceptibility and outcome in macaque tuberculosis infection.Tuberculosis (Edinburgh, Scotland) · 2017Article
- Development of genetically engineered iNKT cells expressing TCRs specific for the M. tuberculosis 38-kDa antigen.Journal of translational medicine · 2015Article
- Role of non-conventional T lymphocytes in respiratory infections: the case of the pneumococcus.PLoS pathogens · 2014Review
- Nonclassical T cells and their antigens in tuberculosis.Cold Spring Harbor perspectives in medicine · 2014Review
- In search of a new paradigm for protective immunity to TB.Nature reviews. Microbiology · 2014Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
CD1d-restricted invariant natural killer T cells (iNKT cells) have been identified as an important type of effector and regulatory T cell, but their roles in the chronic infectious diseases caused by Mycobacterium tuberculosis and Mycobacterium leprae remain poorly defined. Here, we studied circulating human iNKT cells in blood samples from tuberculosis (TB) and leprosy patients. We found that the percentages of iNKT cells among total circulating T cells in TB and leprosy patients were not significantly different from those in normal controls. However, both TB and leprosy patients showed a selective reduction of the proinflammatory CD4(-)CD8beta(-) (DN) iNKT cells with a proportionate increase in the CD4(+) iNKT cells. Similar phenotypic alterations in circulating iNKT cells were observed in a mouse model of M. tuberculosis infection. Taken together, these findings indicate that the selective reduction of circulating DN iNKT cells is associated with chronic infections caused by M. tuberculosis and M. leprae.
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Registered trials
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