ArticleMolecular and biochemical parasitology2008
A drug-selected Plasmodium falciparum lacking the need for conventional electron transport.
Article in Molecular and biochemical parasitology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Advancements in CRISPR-Cas Systems for Genome Editing towards Eradication of Human Microbial Pathogens.Molecular biotechnology · 2026Review
- Novel heterospirocyclic antimalarials with activity against artemisinin- and multidrug-resistant P. falciparum malaria.International journal for parasitology. Drugs and drug resistance · 2025Article
- Pharmacological inhibition of key metabolic pathways attenuates Leishmania spp infection in macrophages.PLoS neglected tropical diseases · 2025Article
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- Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.Science (New York, N.Y.) · 2022Article
- Robenidine Analogues Are Potent Antimalarials in Drug-ResistantACS infectious diseases · 2021Article
- Atypical Molecular Basis for Drug Resistance to Mitochondrial Function Inhibitors in Plasmodium falciparum.Antimicrobial agents and chemotherapy · 2021Article
- Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum (PfNDH2) is dispensable in the asexual blood stages.PloS one · 2019Article
- Chromobacterium spp. mediate their anti-Plasmodium activity through secretion of the histone deacetylase inhibitor romidepsin.Scientific reports · 2018Article
- Progress in the Optimization of 4(1Chimia · 2017Article
- Article
- Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc1 Inhibition Strategy for Malaria.Antimicrobial agents and chemotherapy · 2016Article
- New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections.Scientific reports · 2016Article
- Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum.Antimicrobial agents and chemotherapy · 2015Article
- Atovaquone tolerance in Plasmodium falciparum parasites selected for high-level resistance to a dihydroorotate dehydrogenase inhibitor.Antimicrobial agents and chemotherapy · 2015Article
- Antimalarial pharmacology and therapeutics of atovaquone.The Journal of antimicrobial chemotherapy · 2013Review
- Quinolone-3-diarylethers: a new class of antimalarial drug.Science translational medicine · 2013Article
- Article
- Design of anti-parasitic and anti-fungal hydroxy-naphthoquinones that are less susceptible to drug resistance.Molecular and biochemical parasitology · 2011Article
- Global response of Plasmodium falciparum to hyperoxia: a combined transcriptomic and proteomic approach.Malaria journal · 2011Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Mitochondrial electron transport is essential for survival in Plasmodium falciparum, making the cytochrome (cyt) bc(1) complex an attractive target for antimalarial drug development. Here we report that P. falciparum cultivated in the presence of a novel cyt bc(1) inhibitor underwent a fundamental transformation in biochemistry to a phenotype lacking a requirement for electron transport through the cyt bc(1) complex. Growth of the drug-selected parasite clone (SB1-A6) is robust in the presence of diverse cyt bc(1) inhibitors, although electron transport is fully inhibited by these same agents. This transformation defies expected molecular-based concepts of drug resistance, has important implications for the study of cyt bc(1) as an antimalarial drug target, and may offer a glimpse into the evolutionary future of Plasmodium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.