ArticleBMC evolutionary biology2008
Cranial bone morphometric study among mouse strains.
Article in BMC evolutionary biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
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- Molecular phylogeny and morphometric divergence of native Korean wild mice (Mus musculus).Laboratory animal research · 2026Article
- Elevated lysosomal mass and enzyme activity in fibroblasts of the Mediterranean mouse Mus spretus.Biology letters · 2026Article
- p75 neurotrophin receptor regulates craniofacial growth and morphology in postnatal development.Frontiers in cell and developmental biology · 2025Article
- The A2ml1-Knockout mouse as an animal model for non-syndromic otitis media.International journal of pediatric otorhinolaryngology · 2024Article
- Important Role of the Ihh Signaling Pathway in Initiating Early Cranial Remodeling and Morphological Specialization inAnimals : an open access journal from MDPI · 2023Article
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- Hypochondroplasia gain-of-function mutation in FGFR3 causes defective bone mineralization in mice.JCI insight · 2023Article
- Intraosseous administration into the skull: Potential blood-brain barrier bypassing route for brain drug delivery.Bioengineering & translational medicine · 2023Article
- Sphenoid Bone Determines the Curvature of the Cranial Vault in Postnatal Skull Development in C57BL/6 Mice.Journal of bone metabolism · 2023Article
- Genetically programmed retinoic acid deficiency during gastrulation phenocopies most known developmental defects due to acute prenatal alcohol exposure in FASD.Frontiers in cell and developmental biology · 2023Article
- Electromagnetic Controlled Closed-Head Model of Mild Traumatic Brain Injury in Mice.Journal of visualized experiments : JoVE · 2022Article
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- Reinforced thinned-skull window for repeated imaging of the neonatal mouse brain.Neurophotonics · 2022Article
- Cranial and Spinal Window Preparation forExperimental neurobiology · 2022Review
- Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy.Nature communications · 2022Article
- MesoNet allows automated scaling and segmentation of mouse mesoscale cortical maps using machine learning.Nature communications · 2021Article
- Morphometric Study ofAnimals : an open access journal from MDPI · 2021Article
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle is known about the molecular mechanism which regulates how the whole cranium is shaped. Mouse models currently available for genetic research include several hundreds of unique inbred strains and genetically engineered mutants. By cross comparing their genomic structures, we can elucidate the cause of any differences in the phenotype between two strains. The craniometry of subspecies, or closely related species, of mice provide a good systemic model to study the relationship between genetic variance and cranial shape evolution. The lack of a quantified framework for comparing and analyzing mouse cranial shape has been a problem. For this reason, we performed quantitative analysis of cranial shape morphology between several mouse strains.
resultsThis article reports on a craniometric assay of seven mouse strains: four inbred strains (C57BL/6J, BALB/cA, C3H/HeJ, and CBA/JNCr) from Mus musculus domesticus (M. m. domesticus); one closed colony strain (ICR) from M. m. domesticus; one inbred strain (MSM/Ms) from Mus musculus molossinus; and, Mus spretus as a strain from a species other than M. m. domesticus. We performed linear measurements and geometric morphometrics. Geometric morphometrics revealed that the cranial characteristics of each strains were clearly distinguishable. We obtained mean scores for each species using the tpsRelw Program and plotted them.
conclusionGeometric morphometrics proved to be useful for identifying and classifying variations in form, and it revealed that M. spretus has a slender cranium when compared with our other strains. The mean cranial shape of C3H or CBA was more similar to MSM/Ms, which is derived from M. m. molossinus, than to either C57BL/6J, BALB, or ICR which are derived from M. m. domesticus. Future work in this field will aid in elucidating the mechanism of whole cranial shape regulation.
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