ArticleBMC plant biology2008
AtMRP6/AtABCC6, an ATP-binding cassette transporter gene expressed during early steps of seedling development and up-regulated by cadmium in Arabidopsis thaliana.
Article in BMC plant biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed, 101 citations in OpenAlex.
- The Multidrug Resistance Protein OsMDR4 Is Involved in Cadmium Absorption in Rice (Plants (Basel, Switzerland) · 2026Article
- Functional Genetic Frontiers in Plant ABC Transporters: Avenues Toward Cadmium Management.International journal of molecular sciences · 2025Review
- Cadmium Stress Response of ABC Transporters inGenes · 2025Article
- Genome-Wide Identification of ATP-Binding Cassette (ABC) Transporter Gene Family and Their Expression Analysis in Response to Anthocyanin Transportation in the Fruit Peel of Eggplant (International journal of molecular sciences · 2025Article
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- Exploring the role of ATP-binding cassette transporters in tomato (Frontiers in plant science · 2025Article
- Haplotypes of ATP-Binding CassetteBiomolecules · 2024Article
- The Uptake, Transfer, and Detoxification of Cadmium in Plants and Its Exogenous Effects.Cells · 2024Review
- Article
- miR397-LACs mediated cadmium stress tolerance in Arabidopsis thaliana.Plant molecular biology · 2023Article
- Reactive oxygen species- and nitric oxide-dependent regulation of ion and metal homeostasis in plants.Journal of experimental botany · 2023Article
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- Characteristics of cadmium accumulation and tolerance in apple plants grown in different soils.Frontiers in plant science · 2023Article
- Advances in Genes-Encoding Transporters for Cadmium Uptake, Translocation, and Accumulation in Plants.Toxics · 2022Review
- Genome-Wide Analysis of the ATP-Binding Cassette (ABC) Transporter Family inInternational journal of molecular sciences · 2022Article
- Exogenous tryptophan application improves cadmium tolerance and inhibits cadmium upward transport in broccoli (Frontiers in plant science · 2022Article
- Review
- Recent advances in physiological and molecular mechanisms of heavy metal accumulation in plants.Environmental science and pollution research international · 2021Review
- Genome-Wide Identification of Soybean ABC Transporters Relate to Aluminum Toxicity.International journal of molecular sciences · 2021Article
- Genome-wide analysis of ATP-binding cassette transporter provides insight to genes related to bioactive metabolite transportation in Salvia miltiorrhiza.BMC genomics · 2021Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundABC proteins constitute one of the largest families of transporters found in all living organisms. In Arabidopsis thaliana, 120 genes encoding ABC transporters have been identified. Here, the characterization of one member of the MRP subclass, AtMRP6, is described.
resultsThis gene, located on chromosome 3, is bordered by AtMRP3 and AtMRP7. Using real-time quantitative PCR (RT-Q-PCR) and the GUS reporter gene, we found that this gene is essentially expressed during early seedling development, in the apical meristem and at initiation point of secondary roots, especially in xylem-opposite pericycle cells where lateral roots initiate. The level of expression of AtMRP6 in response to various stresses was explored and a significant up-regulation after cadmium (Cd) treatment was detected. Among the three T-DNA insertion lines available from the Salk Institute library, two knock-out mutants, Atmrp6.1 and Atmrp6.2 were invalidated for the AtMRP6 gene. In the presence of Cd, development of leaves was more affected in the mutants than wild-type plants, whereas root elongation and ramification was comparable.
conclusionThe position of AtMRP6 on chromosome 3, flanked by two other MRP genes, (all of which being induced by Cd) suggests that AtMRP6 is part of a cluster involved in metal tolerance, although additional functions in planta cannot be discarded.
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