ArticleBMC developmental biology2008
Er81 is a downstream target of Pax6 in cortical progenitors.
Article in BMC developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- The Role of Pea3 Transcription Factor Subfamily in the Nervous System.Molecular neurobiology · 2025Review
- Bleaching protection and axial sectioning in fluorescence nanoscopy through two-photon activation at 515 nm.Nature communications · 2024Article
- Genoarchitectonic Compartmentalization of the Embryonic Telencephalon: Insights From the Domestic Cat.Frontiers in neuroanatomy · 2021Article
- mSWI/SNF (BAF) Complexes Are Indispensable for the Neurogenesis and Development of Embryonic Olfactory Epithelium.PLoS genetics · 2016Article
- Altered proliferative ability of neuronal progenitors in PlexinA1 mutant mice.The Journal of comparative neurology · 2016Article
- Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development.Nucleic acids research · 2015Article
- Pax6 controls centriole maturation in cortical progenitors through Odf2.Cellular and molecular life sciences : CMLS · 2015Article
- Regulation of cerebral cortical neurogenesis by the Pax6 transcription factor.Frontiers in cellular neuroscience · 2015Article
- Molecular Pathways Underlying Projection Neuron Production and Migration during Cerebral Cortical Development.Frontiers in neuroscience · 2015Review
- Transcriptional analysis of apoptotic cerebellar granule neurons following rescue by gastric inhibitory polypeptide.International journal of molecular sciences · 2014Article
- Pax6 regulates the formation of the habenular nuclei by controlling the temporospatial expression of Shh in the diencephalon in vertebrates.BMC biology · 2014Article
- The ETS transcription factor Etv1 mediates FGF signaling to initiate proneural gene expression during Xenopus laevis retinal development.Mechanisms of development · 2014Article
- BAF chromatin remodeling complex: cortical size regulation and beyond.Cell cycle (Georgetown, Tex.) · 2013Article
- Article
- Neural progenitors, patterning and ecology in neocortical origins.Frontiers in neuroanatomy · 2013Review
- MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Isoform- and dose-sensitive feedback interactions between paired box 6 gene and delta-catenin in cell differentiation and death.Experimental cell research · 2010Article
- Role of Fgf8 signalling in the specification of rostral Cajal-Retzius cells.Development (Cambridge, England) · 2010Article
- Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development.BMC developmental biology · 2009Article
- Selective cortical layering abnormalities and behavioral deficits in cortex-specific Pax6 knock-out mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the transcription factor Pax6 plays an essential role in neurogenesis, layer formation and arealization in the developing mammalian cortex, the mechanisms by which it accomplishes these regulatory functions are largely unknown. Pax6 and the ETS family transcription factor Er81, which is presumed to play a role in the specification of a sublineage of layer 5 projection neurons, are expressed with a prominent rostrolateral-high to caudomedial-low gradient in cortical progenitors. In the absence of functional Pax6, progenitors do not express Er81 and the rostrolateral cortex lacks Er81-positive layer 5 neurons. In this study, we investigated the transcriptional regulation of Er81 and provide evidence that Er81 is a direct target of Pax6.
resultsWe identified and analyzed the regulatory function of an evolutionarily conserved upstream DNA sequence in the putative mouse Er81 promoter. Three potential Pax6 binding sites were identified in this region. We found that the presence of one of these sites is necessary and sufficient for full activation of the Er81 promoter in Pax6-transfected HeLa cells, while other still unknown factors appear to contribute to Er81 promoter activity in cortical progenitors and neuronal cells. The results suggest that endogenous Pax6, which is expressed at the highest level in progenitors of the rostrolateral cortex, exerts region-specific control of Er81 activity, thus specifying a subpopulation of layer 5 projection neurons.
conclusionWe conclude that the genetic interplay between the transcription factors, Pax6 and Er81, is responsible, in part, for the regional specification of a distinct sublineage of layer 5 projection neurons.
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