Evidence map›Paper›PMID 18307108›Full record

ReviewCritical reviews in biochemistry and molecular biology

The Drosophila circadian pacemaker circuit: Pas De Deux or Tarantella?

Vasu Sheeba, Maki Kaneko, Vijay Kumar Sharma, Todd C Holmes

Abstract readReview
In one paragraph

Review in Critical reviews in biochemistry and molecular biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
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  4. Evaluating the Autonomy of theFrontiers in cellular neuroscience · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vasu SheebaDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, California 92612, USA.
Maki Kaneko
Vijay Kumar Sharma
Todd C Holmes

Funding

Electrical Signaling in a Circadian Pacemaker CircuitR01NS046750 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI HOLMES, TODD C · 2004 to 2013
$2.4M
Transgenic Electrical Silencing of a Neural CircuitR21DA016352 · NIDA · NEW YORK UNIVERSITY · PI HOLMES, TODD C · 2002 to 2003
$290k
NIDA NIH HHS DA016352NIDA NIH HHS R21 DA016352NINDS NIH HHS NS046750NINDS NIH HHS R01 NS046750
6 · The paper itself

Abstract

Molecular genetic analysis of the fruit fly Drosophila melanogaster has revolutionized our understanding of the transcription/translation loop mechanisms underlying the circadian molecular oscillator. More recently, Drosophila has been used to understand how different neuronal groups within the circadian pacemaker circuit interact to regulate the overall behavior of the fly in response to daily cyclic environmental cues as well as seasonal changes. Our present understanding of circadian timekeeping at the molecular and circuit level is discussed with a critical evaluation of the strengths and weaknesses of present models. Two models for circadian neural circuits are compared: one that posits that two anatomically distinct oscillators control the synchronization to the two major daily morning and evening transitions, versus a distributed network model that posits that many cell-autonomous oscillators are coordinated in a complex fashion and respond via plastic mechanisms to changes in environmental cues.

Indexed as

Models, NeurologicalAnimalsCircadian RhythmDrosophilaNeural PathwaysNeurons

Identifiers

PMID18307108
PMCPMC2597196

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.