ArticleProceedings of the National Academy of Sciences of the United States of America1991
Purified kinesin promotes vesicle motility and induces active sliding between microtubules in vitro.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 122 citations in OpenAlex.
- An acentrosomal aster with atypical microtubule polarity recruits cytokinesis signals to its center in Xenopus egg extracts.Journal of cell science · 2025Article
- Direct detection of deformation modes on varying length scales in active biopolymer networks.bioRxiv : the preprint server for biology · 2025Article
- A small-molecule activator of kinesin-1 drives remodeling of the microtubule network.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Filament rigidity and connectivity tune the deformation modes of active biopolymer networks.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Enhanced Dynamics of Confined Cytoskeletal Filaments Driven by Asymmetric Motors.Biophysical journal · 2017Article
- A single-headed fission yeast myosin V transports actin in a tropomyosin-dependent manner.The Journal of cell biology · 2016Article
- Active contraction of microtubule networks.eLife · 2015Article
- Emergent complexity of the cytoskeleton: from single filaments to tissue.Advances in physics · 2013Review
- Charcot-Marie-Tooth disease and intracellular traffic.Progress in neurobiology · 2012Review
- Biophysics of mitosis.Quarterly reviews of biophysics · 2012Review
- Active multistage coarsening of actin networks driven by myosin motors.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Cytoplasmic microtubule sliding: An unconventional function of conventional kinesin.Communicative & integrative biology · 2010Article
- Kinesin-1 heavy chain mediates microtubule sliding to drive changes in cell shape.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Kinesin's light chains inhibit the head- and microtubule-binding activity of its tail.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Collective alignment of polar filaments by molecular motors.The European physical journal. E, Soft matter · 2009Article
- Instabilities in a two-dimensional polar-filament--motor system.The European physical journal. E, Soft matter · 2008Article
- Taxol crystals can masquerade as stabilized microtubules.PloS one · 2008Article
- Conventional kinesin mediates microtubule-microtubule interactions in vivo.Molecular biology of the cell · 2006Article
- Nonlinear competition between asters and stripes in filament-motor systems.The European physical journal. E, Soft matter · 2005Article
- Self-organized density patterns of molecular motors in arrays of cytoskeletal filaments.Biophysical journal · 2005Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined the ability of kinesin to support the movement of adrenal medullary chromaffin granules on microtubules in a defined in vitro system. We found that kinesin and ATP are all that is required to support efficient (33% vesicle motility) and rapid (0.4-0.6 micron/s) translocation of secretory granule membranes on microtubules in the presence of a low-salt motility buffer. Kinesin also induced the formation of microtubule asters in this buffer, with the plus ends of microtubules located at the center of each aster. This observation indicates that kinesin is capable of promoting active sliding between microtubules toward their respective plus ends, a movement analogous to that of anaphase b in the mitotic spindle. The fact that vesicle translocation, microtubule sliding, and microtubule-dependent kinesin ATPase activities are all enhanced in low-salt buffer establishes a functional parallel between this translocator and other motility ATPases, myosin, and dynein.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.