ArticleProceedings of the National Academy of Sciences of the United States of America1991
Interleukin 6 enhances a cellular activity that functionally substitutes for E1A protein in transactivation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 60 citations in OpenAlex.
- Article
- Advances in Gene Delivery Systems.Pharmaceutical medicine · 2011Article
- Vaccination with Ad5 vectors expands Ad5-specific CD8 T cells without altering memory phenotype or functionality.PloS one · 2010Article
- Using viral vectors as gene transfer tools (Cell Biology and Toxicology Special Issue: ETCS-UK 1 day meeting on genetic manipulation of cells).Cell biology and toxicology · 2010Article
- Replication of an integrin targeted conditionally replicating adenovirus on primary ovarian cancer spheroids.Cancer gene therapy · 2003Article
- Nonneurotropic adenovirus: a vector for gene transfer to the brain and gene therapy of neurological disorders.International review of neurobiology · 2003Review
- Viral vectors for vascular gene therapy.Experimental and clinical cardiology · 2002Article
- Human papillomavirus E6E7-mediated adenovirus cell killing: selectivity of mutant adenovirus replication in organotypic cultures of human keratinocytes.Journal of virology · 2001Article
- Intra-CSF administered recombinant adenovirus causes an immune response-mediated toxicity.Gene therapy · 2000Article
- Insulation from viral transcriptional regulatory elements improves inducible transgene expression from adenovirus vectors in vitro and in vivo.Gene therapy · 2000Article
- Induction of apoptosis and G2/M arrest by infection with replication-deficient adenovirus at high multiplicity of infection.Gene therapy · 1999Article
- Overexpression of C/EBPbeta represses human papillomavirus type 18 upstream regulatory region activity in HeLa cells by interfering with the binding of TATA-binding protein.Journal of virology · 1998Article
- Persistence of recombinant adenovirus in vivo is not dependent on vector DNA replication.Journal of virology · 1997Article
- Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo.Journal of virology · 1996Article
- A novel C/EBP beta-YY1 complex controls the cell-type-specific activity of the human papillomavirus type 18 upstream regulatory region.Journal of virology · 1996Article
- Efficient dual transcomplementation of adenovirus E1 and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit.Journal of virology · 1996Article
- The human topoisomerase I gene promoter is regulated by NF-IL6.Molecular and cellular biology · 1995Article
- Adenoviral-mediated gene transfer to fetal pulmonary epithelia in vitro and in vivo.The Journal of clinical investigation · 1995Article
- NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor necrosis factor alpha and interleukin-1.Molecular and cellular biology · 1994Article
- Characterization of transgenic mice containing adenovirus early region 3 genomic DNA.Journal of virology · 1994Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
An interleukin 6 (IL-6)-regulated cellular activity in HepG2 cells is found to functionally substitute for the transcriptional transactivator product of the adenovirus transforming gene E1A in transactivating E1A-dependent and E1A-responsive viral early genes. Mutant viruses deficient in E1A expression replicate in HepG2 cells. Induction with IL-6 leads to significant enhancement of synthesis of viral early E1B and E2ae mRNAs by greater than 30-fold and increases viral replication to the wild-type levels. The E1A-substituting activity activates E1A-responsive promoters in transient transfection, and this transcriptional activity is regulated by IL-6 induction. Formation of distinct protein-promoter complexes by binding of proteins in nuclear extracts prepared from HepG2 cells to the E1A-dependent E2ae promoter further supports the possibility that this activity may be a nuclear component in the IL-6 signal transduction pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.