ArticleProceedings of the National Academy of Sciences of the United States of America1991
Colocalization of lymphocytes bearing gamma delta T-cell receptor and heat shock protein hsp65+ oligodendrocytes in multiple sclerosis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
66 citing papers in PubMed, 285 citations in OpenAlex.
- Recombinant rat heat shock protein 70 (rrHSP70) may promote remyelination by regulating microglia/macrophages and oligodendrocytes in a toxin-induced demyelination animal model.Frontiers in immunology · 2026Article
- Decoding the role of large heat shock proteins in the progression of neuroinflammation-mediated neurodegenerative disorders.Neuroprotection (Chichester, England) · 2025Review
- Key actors in neuropathophysiology: The role of γδ T cells.European journal of immunology · 2024Review
- Review
- Unconventional T cells in brain homeostasis, injury and neurodegeneration.Frontiers in immunology · 2023Review
- γδ T Cells Activated in Different Inflammatory Environments Are Functionally Distinct.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- γδ T Cells Participating in Nervous Systems: A Story of Jekyll and Hyde.Frontiers in immunology · 2021Review
- Reduction of Peripheral Blood iNKT and γδT Cells in Patients With Parkinson's Disease: An Observational Study.Frontiers in immunology · 2020Observational
- The Role of Gamma-Delta T Cells in Diseases of the Central Nervous System.Frontiers in immunology · 2020Review
- Long-term use of interferon-β in multiple sclerosis increases Vδ1Journal of neuroinflammation · 2019Article
- γδ T Cells Contribute to the Outcome of Murine Fulminant Viral Hepatitis via Effector Cytokines TNF-α and IFN-γ.Current medical science · 2018Article
- Association of Decreased Percentage of Vδ2Frontiers in immunology · 2018Article
- Retinoic acid suppresses IL-17 production and pathogenic activity of γδ T cells in CNS autoimmunity.Immunology and cell biology · 2016Article
- Taming pathogenic γδ T cells with vitamin A.Immunology and cell biology · 2016Article
- Danger Signals and Graft-versus-host Disease: Current Understanding and Future Perspectives.Frontiers in immunology · 2016Review
- Microglia Induce Neurotoxic IL-17+ γδ T Cells Dependent on TLR2, TLR4, and TLR9 Activation.PloS one · 2015Article
- Crystal structure of Vδ1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human γδ T cells.Immunity · 2013Article
- IL-17 producing T cells in mouse models of multiple sclerosis and rheumatoid arthritis.Journal of molecular medicine (Berlin, Germany) · 2012Review
- Activated gammadelta T cells promote the activation of uveitogenic T cells and exacerbate EAU development.Investigative ophthalmology & visual science · 2011Article
- Role of γδ T cells in antibody production and recovery from SFV demyelinating disease.Journal of neuroimmunology · 2011Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The presence of T lymphocytes bearing the gamma delta T-cell receptor (TCR gamma delta) has been studied immunocyto-chemically in central nervous system (CNS) tissue from 13 patients with multiple sclerosis (MS), 4 with inflammatory non-MS CNS disorders, 6 with other neurological diseases, and 3 with nonneurologic conditions. Twenty-eight of 43 MS lesions contained TCR gamma delta cells and these were most frequently found in chronically demyelinated areas, in contrast to the previously studied CD4+, CD8+ (TCR alpha beta) population, which predominated in more active lesions. Some TCR gamma delta lymphocytes had an unusual morphology with long dendritic processes, which were sometimes interconnected forming a network. Because it is generally believed that TCR gamma delta lymphocytes function in a cytotoxic fashion in association with heat shock proteins (hsp), we examined the colocalization of TCR gamma delta cells with 65- and 70-kDa hsp (hsp65 and hsp70) in MS lesions. Hsp65 was expressed on immature oligodendrocytes at the margins of chronic lesions containing TCR gamma delta lymphocytes. The coexpression of these molecules might imply functional relationships perhaps of significance to the chronicity of the MS disease process and the failure of CNS remyelination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.