ArticleYonsei medical journal2008
Rarity of TLR4 Asp299Gly and Thr399Ile polymorphisms in the Korean population.
Article in Yonsei medical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Quantitative assessment of TLR4 gene polymorphisms and T2DM risk: A meta-analysis.Molecular genetics & genomic medicine · 2020Pooled it
- Association between Toll-like receptor 4 Asp299Gly polymorphism and coronary heart disease susceptibility.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Pooled it
- Identification of novel amino acid variants in the Han Chinese population that impair toll-like receptor 4 signaling and confer hyporesponsiveness to lipopolysaccharide.Frontiers in immunology · 2025Article
- Molecular Effect of Variants in Toll-like Receptor 4 Gene in Saudi Patients with Type 2 Diabetes Mellitus.Cells · 2023Article
- Toll-like receptor-4 299Gly allele is associated with Guillain-Barré syndrome in Bangladesh.Annals of clinical and translational neurology · 2019Article
- Promoter Polymorphism of Toll-Like Receptor 4 is Associated with a Decreased Risk of Coronary Artery Disease: A Case-Control Study in the Chinese Han Population.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Genetic Polymorphisms of TLR4 and MICA are Associated with Severity of Trachoma Disease in Tanzania.Autoimmune and infectious diseases : open access · 2016Article
- Article
- TLR4 inactivation protects from graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.Cellular & molecular immunology · 2013Article
- Multiple Genotypes of the Commonly Co-Segregating Toll-Like Receptor 4 Asp299Gly and Thr399Ile in Baluchi Malaria Patients from Iran.Cell journal · 2013Article
- Toll-like receptor 4 (TLR4) polymorphisms in Iranian patients with visceral leishmaniasis.Molecular biology reports · 2012Article
- Frequency of TLR 2, 4, and 9 gene polymorphisms in Chinese population and their susceptibility to type 2 diabetes and coronary artery disease.Journal of biomedicine & biotechnology · 2012Article
- Lack of association of TLR4 gene Asp299Gly and Thr399Ile polymorphisms with rheumatoid arthritis in Chinese Han population of Yunnan Province.Rheumatology international · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeActivation of the innate immune system and chronic low-grade inflammation are thought to be involved in the pathogenesis of atherosclerosis and also thought to be associated with type 2 diabetes and its complications. As a receptor for bacterial lipopolysaccharide and heat-shock proteins, Toll-like receptor 4 (TLR4) is one of the central regulators of the immune response. Recent studies have reported an association between TLR4 polymorphisms and diabetes and its complications in Caucasian populations. MATERIALS AND
methodsIn this study, we analyzed the association between TLR4 gene polymorphisms in patients with features of type 2 diabetes and healthy controls in Korea. Two polymorphisms of the TLR4 gene (Asp299Gly and Thr399Ile) were examined in 225 diabetic patients and 153 healthy controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and single-strand conformation polymorphism (SSCP).
resultsNo Asp299Gly or Thr399Ile mutations were detected in any of the 378 subjects. Seven subjects from each group who had slightly different SSCP patterns were selected for sequencing, but we found no TLR4 polymorphisms on Exon3. The Asp299Gly and Thr399Ile TLR4 gene polymorphisms were absent in both groups, which was similar to the results for Japanese and Chinese Han subjects.
conclusionOur data and other Asian data suggest that a racial difference can be found in the frequency of the TLR4 polymorphism.
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