SynthesisWorld journal of surgery2008
Thyroid incidentaloma: an evidence-based assessment of management strategy.
Synthesis in World journal of surgery, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- German Association of Endocrine Surgeons practice guidelines for the surgical treatment of benign thyroid disease.Langenbeck's archives of surgery · 2011Guideline
- Positron emission tomography detected thyroid incidentaloma.Annals of the Royal College of Surgeons of England · 2013Article
- Do family physicians request ultrasound scans appropriately?Canadian family physician Medecin de famille canadien · 2011Article
- The role of 18F-fluorodeoxyglucose positron emission tomography in thyroid neoplasms.The oncologist · 2011Review
- Incidental thyroid abnormalities identified on neck US for non-thyroid disorders.Pediatric radiology · 2010Article
- Management of thyroid nodules and surgery for differentiated thyroid cancer.Clinical oncology (Royal College of Radiologists (Great Britain)) · 2010Review
- Thyroid incidentalomas: to treat or not to treat.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2010Review
- Controversies and challenges in the management of well-differentiated thyroid cancer.The Indian journal of surgery · 2009Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPalpable thyroid nodules are present in 4-7% of the population and their prevalence increases with age. Thyroid incidentalomas-impalpable nodules detected fortuitously during a radiological investigation-may be found in up to 50% of patients. Although numerous guidelines exist that indicate the appropriate management of palpable thyroid nodules, there are no accepted guidelines for the increasingly common thyroid incidentaloma. Presently no level I or II evidence exists on this topic.
methodsSystematic review of the literature using evidence-based criteria was performed.
resultsThyroid incidentalomas are common and are mostly benign lesions. A small proportion is malignant, mainly papillary thyroid microcarcinomas (PTMC). Lesions <5 mm in diameter, even if PTMC, exceptionally metastasize and can be safely left. Lesions between 5 mm and 9 mm without sinister radiological features need not be investigated. The appropriate follow-up is controversial.
conclusionIt is unlikely that a trial of sufficient power to demonstrate or refute the beneficial effects of presymptomatic investigation of thyroid nodules will take place. We propose a pragmatic approach based on current evidence that balances the benefit of early diagnosis and treatment with the cost to the patient and the healthcare system associated with unnecessary investigations and surgery.
Indexed as
Identifiers
18305991What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.