ArticleVirchows Archiv : an international journal of pathology2008
Down-regulation of the metastasis suppressor protein KAI1/CD82 correlates with occurrence of metastasis, prognosis and presence of HPV DNA in human penile squamous cell carcinoma.
Article in Virchows Archiv : an international journal of pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 59 citations in OpenAlex.
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- Mesenchymal progenitor cells from non-inflamed versus inflamed synovium post-ACL injury present with distinct phenotypes and cartilage regeneration capacity.Stem cell research & therapy · 2023Article
- [Conventional grading vs. molecular grading : Decision aids for clinical routine].Der Urologe. Ausg. A · 2021Review
- Assessment of TSPAN Expression Profile and Their Role in the VSCC Prognosis.International journal of molecular sciences · 2021Article
- Role of Tetraspanins in Hepatocellular Carcinoma.Frontiers in oncology · 2021Review
- [Molecular tumor board penile cancer-a challenge].Der Urologe. Ausg. A · 2019Review
- Clinicopathological significance ofOncotarget · 2018Article
- Prognostic role of CD82/KAI1 in multiple human malignant neoplasms: a meta-analysis of 31 studies.OncoTargets and therapy · 2017Article
- Normal viability of Kai1/Cd82 deficient mice.Molecular carcinogenesis · 2014Article
- Molecular research in penile cancer-lessons learned from the past and bright horizons of the future?International journal of molecular sciences · 2013Review
- Penile cancer: current therapy and future directions.Annals of oncology : official journal of the European Society for Medical Oncology · 2013Review
- The role of annexins I, II and IV in tumor development, progression and metastasis of human penile squamous cell carcinomas.World journal of urology · 2011Article
- Tetraspanins and tumor progression.Clinical & experimental metastasis · 2011Review
- Genomic-wide analysis of lymphatic metastasis-associated genes in human hepatocellular carcinoma.World journal of gastroenterology · 2009Article
- Tetraspanins: push and pull in suppressing and promoting metastasis.Nature reviews. Cancer · 2009Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In penile squamous cell carcinoma (PSCC), the outcome largely depends on early detection and resection of inguinal lymph node metastases. We investigated the role of metastasis suppressor protein kang ai 1 (KAI1)/cluster of differentiation 82 (CD82), which is known to be of prognostic significance for a wide variety of cancers. Moreover, we analysed the tumours for human papillomavirus (HPV) DNA and loss of heterozygosity at the 11p11.2 locus. Tissue samples of 30 primary PSCCs were investigated immunohistochemically using an anti-KAI1/CD82 polyclonal antibody. The expression was assessed according to the degree of KAI1/CD82-positive tumour cells as positive, decreased or negative. The presence of HPV6/11, HPV16 and HPV18 DNA was analysed by polymerase chain reaction. All patients with decreased or negative expression of KAI1/CD82 in primary lesions had lymph node metastases (p = 0.0002). Patients with positive KAI1/CD82 expression showed a significant better prognosis for survival compared to the other groups (p = 0.0042). Presence of HPV DNA was associated with decreased or negative KAI1/CD82 expression. Lacking or decreased expression of metastasis suppressor gene KAI1/CD82 appears to be a prognostic parameter for the occurrence of lymph node metastases in PSCC. Our study suggests an association of decreased KAI1/CD82 expression with tumour progression, development of metastases and disease-specific death.
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