Evidence map›Paper›PMID 18305489›Full record

ArticleGenes and immunity2008

Evaluating linkage disequilibrium and recombination provides a haplotype-tagging SNP panel of the major histocompatibility complex in African Americans.

J M Kelley, L B Hughes, R Feng, N Liu, M A Padilla, L K Vaughan, S L Bridges

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Genes and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

J M KelleyDivision of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham (UAB), AL 35294-2182, USA.
L B Hughes
R Feng
N Liu
M A Padilla
L K Vaughan
S L Bridges
University of Alabama at Birmingham · US

Funding

Zevalin Radioimmunotherapy Using a Modified TreatmentM01RR000032 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI RICH, ROBERT R. · 1985 to 2008
$23.6M
Sex Related Determinants Of Pain In FibromyalgiaP60AR048095 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BRIDGES, S LOUIS · 2002 to 2012
$11.7M
RA-Related Autoantibodies in Healthy FDR of RA PatientsR01AR051394 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI NORRIS, JILL M · 2005 to 2011
$3.0M
TRAINING PROGRAM IN RHEUMATIC DISEASES RESEARCHT32AR007450 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BRIDGES, S LOUIS · 1986 to 2011
$2.2M
Predictors of Treatment Response in Early Aggressive RAR01AR052658 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BRIDGES, S LOUIS · 2004 to 2007
$1.2M
CLEAR-264002247N01AR002247 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2000 to 2004
$805k
NCRR NIH HHS M01 RR000032NCRR NIH HHS M01 RR00032NIAMS NIH HHS N01 AR02247NIAMS NIH HHS P60 AR048095NIAMS NIH HHS R01 AR051394NIAMS NIH HHS R01 AR052658NIAMS NIH HHS R01 AR052658-02S1NIAMS NIH HHS R01 AR51394NIAMS NIH HHS T32 AR07450
6 · The paper itself

Abstract

The major histocompatibility complex (MHC) (Chromosome 6p21.3) is a dynamic, immune gene-rich region that is associated with multiple diseases. Haplotype-tagging single-nucleotide polymorphism (htSNP) panels for the MHC can aid association studies but have only been reported for African, Asian and Caucasian populations to date. We genotyped 2154 SNPs spanning a 3.8-Mb region of the classical MHC in 94 healthy African Americans using Illumina BeadArray technology. We describe the haplotype structure of the MHC in African Americans, calculate the recombination rate (0.35 cM Mb(-1)) across the region, identify recombination hot spots and develop a panel of htSNPs for future genetic association studies in this population. We conclude that while patterns of LD and recombination are similar within the MHC to that reported in other populations, differences in minor allele frequency at specific markers necessitates an htSNP panel unique to African Americans, which we provide here for use in future genetic association studies.

Indexed as

Linkage DisequilibriumBlack or African AmericanGene FrequencyHaplotypesHumansMajor Histocompatibility ComplexPolymorphism, Single NucleotideRecombination, GeneticUnited States

Identifiers

PMID18305489
OpenAlexW2009002947

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.