ArticleNature2008
SLAC1 is required for plant guard cell S-type anion channel function in stomatal signalling.
Article in Nature, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 356 papers.
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Who cites it
356 citing papers in PubMed, 837 citations in OpenAlex.
- Guard cell signal transduction mechanisms controlling stomatal movements by light, abscisic acid, CO2, VPD and heat.Plant physiology · 2026Review
- COJournal of integrative plant biology · 2026Article
- Evolutionary tuning of the molecular charge state of UBP24 shapes responses to high temperature.Nature plants · 2026Article
- Cross-ribbon conformation defines peptide recognition in SCREW/CTNIP-NUT/HSL3 signalling.Nature plants · 2026Article
- Abscisic acid-regulated stability of CmABF1 and CmBRM modulates salt tolerance in chrysanthemum via epigenetic regulation ofScience advances · 2026Article
- Synthetic ion channel inhibitors enhance plant drought tolerance.Nature communications · 2026Article
- Research Progress on Chloride Channel- and Transporter- Related Gene Families in Plants.International journal of molecular sciences · 2026Review
- SlSLAH2 mediates malate exudation and contributes to aluminum tolerance.Nature communications · 2026Article
- A guard cell carbonic anhydrase binds and regulates SLAC1 separate from its catalytic activity.Nature communications · 2026Article
- Divergent Transcriptional Architectures Beyond Core CAM Genes in Facultative and Constitutive CAM Species in Tillandsia L.Molecular ecology · 2026Article
- A drought stress-responsive metabolite malate modulates stomatal responses through G-protein-dependent pathway in grapevine and Arabidopsis.Molecular horticulture · 2026Article
- Bioorganic studies on the nyctinastic leaf-movement of plants.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2026Review
- Genome-wide identification and functional characterization of PP2C genes in the wild relative of sweet potato Ipomoea trifida.BMC plant biology · 2025Article
- Structural insights into the coordinated regulation of the SLAH family in Arabidopsis thaliana.Nature communications · 2025Article
- Pathogen-induced condensation of the guard cell RNA-binding protein SAIR1 fine-tunes translation for immunity.Nature plants · 2025Article
- OPEN STOMATA 1 activates SLAC1 anion channel primarily through CPK15 in ABA-induced stomatal closure inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Stomatal signaling under drought: integrating hormonal pathways for crop resilience.Plant cell reports · 2025Review
- ALMT12 interacts with and inhibits SLAC1 to modulate stomatal movements and enhance plant biomass.Plant physiology · 2025Article
- Stomatal CO2 sensing in plants: control of gas exchange and interactions with environmental stimuli.Plant & cell physiology · 2025Review
- A comparative transcriptomic analysis provides insights into molecular mechanisms driving salt tolerance in soybean.Scientific reports · 2025Article
296 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 4 countries.
Funding
Abstract
Stomatal pores, formed by two surrounding guard cells in the epidermis of plant leaves, allow influx of atmospheric carbon dioxide in exchange for transpirational water loss. Stomata also restrict the entry of ozone--an important air pollutant that has an increasingly negative impact on crop yields, and thus global carbon fixation and climate change. The aperture of stomatal pores is regulated by the transport of osmotically active ions and metabolites across guard cell membranes. Despite the vital role of guard cells in controlling plant water loss, ozone sensitivity and CO2 supply, the genes encoding some of the main regulators of stomatal movements remain unknown. It has been proposed that guard cell anion channels function as important regulators of stomatal closure and are essential in mediating stomatal responses to physiological and stress stimuli. However, the genes encoding membrane proteins that mediate guard cell anion efflux have not yet been identified. Here we report the mapping and characterization of an ozone-sensitive Arabidopsis thaliana mutant, slac1. We show that SLAC1 (SLOW ANION CHANNEL-ASSOCIATED 1) is preferentially expressed in guard cells and encodes a distant homologue of fungal and bacterial dicarboxylate/malic acid transport proteins. The plasma membrane protein SLAC1 is essential for stomatal closure in response to CO2, abscisic acid, ozone, light/dark transitions, humidity change, calcium ions, hydrogen peroxide and nitric oxide. Mutations in SLAC1 impair slow (S-type) anion channel currents that are activated by cytosolic Ca2+ and abscisic acid, but do not affect rapid (R-type) anion channel currents or Ca2+ channel function. A low homology of SLAC1 to bacterial and fungal organic acid transport proteins, and the permeability of S-type anion channels to malate suggest a vital role for SLAC1 in the function of S-type anion channels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.