ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Gamma oscillatory firing reveals distinct populations of pyramidal cells in the CA1 region of the hippocampus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
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Who cites it
94 citing papers in PubMed.
- Article
- Ripple contributions to human memory: making the spiking content count.Nature reviews. Neuroscience · 2025Review
- Dynamic gamma modulation of hippocampal place cells predominates development of theta sequences.eLife · 2025Article
- Development of Differential Sublaminar Feedforward Inhibitory Circuits in CA1 Hippocampus RequiresThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Communication in Brain Circuits and Systems: a Primer.IEEE International Symposium on Circuits and Systems proceedings. IEEE International Symposium on Circuits and Systems · 2025Article
- Article
- Morpho-electric diversity of human hippocampal CA1 pyramidal neurons.Cell reports · 2024Article
- The medial septum controls hippocampal supra-theta oscillations.Nature communications · 2023Article
- Uncorrelated bilateral cortical input becomes timed across hippocampal subfields for long waves whereas gamma waves are largely ipsilateral.Frontiers in cellular neuroscience · 2023Article
- Article
- Ripple band phase precession of place cell firing during replay.Current biology : CB · 2022Article
- Rhythms of human attention and memory: An embedded process perspective.Frontiers in human neuroscience · 2022Review
- Rapid Spectral Dynamics in Hippocampal Oscillons.Frontiers in computational neuroscience · 2022Article
- Time to put the mammillothalamic pathway into context.Neuroscience and biobehavioral reviews · 2021Review
- Disorganization of Oscillatory Activity in Animal Models of Schizophrenia.Frontiers in neural circuits · 2021Review
- Focal Dorsal Hippocampal Nav1.1 Knock Down Alters Place Cell Temporal Coordination and Spatial Behavior.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Reactivated Spatial Context Guides Episodic Recall.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Theta Oscillations in Human Memory.Trends in cognitive sciences · 2020Review
- The Role of Hierarchical Dynamical Functions in Coding for Episodic Memory and Cognition.Journal of cognitive neuroscience · 2019Article
- μ-Opioid receptor activation modulates CA3-to-CA1 gamma oscillation phase-coupling.IBRO reports · 2019Article
34 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
Hippocampal place cells that fire together within the same cycle of theta oscillations represent the sequence of positions (movement trajectory) that a rat traverses on a linear track. Furthermore, it has been suggested that the encoding of these and other types of temporal memory sequences is organized by gamma oscillations nested within theta oscillations. Here, we examined whether gamma-related firing of place cells permits such discrete temporal coding. We found that gamma-modulated CA1 pyramidal cells separated into two classes on the basis of gamma firing phases during waking theta periods. These groups also differed in terms of their spike waveforms, firing rates, and burst firing tendency. During gamma oscillations one group's firing became restricted to theta phases associated with the highest gamma power. Consequently, on the linear track, cells in this group often failed to fire early in theta-phase precession (as the rat entered the place field) if gamma oscillations were present. The second group fired throughout the theta cycle during gamma oscillations, and maintained gamma-modulated firing at different stages of theta-phase precession. Our results suggest that the two different pyramidal cell classes may support different types of population codes within a theta cycle: one in which spike sequences representing movement trajectories occur across subsequent gamma cycles nested within each theta cycle, and another in which firing in synchronized gamma discharges without temporal sequences encode a representation of location. We propose that gamma oscillations during theta-phase precession organize the mnemonic recall of population patterns representing places and movement paths.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.