ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Selective impairment of the cerebellar C1 module involved in rat hind limb control reduces step-dependent modulation of cutaneous reflexes.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Cerebellum Lecture: the Cerebellar Nuclei-Core of the Cerebellum.Cerebellum (London, England) · 2024Review
- Cerebellar connectivity maps embody individual adaptive behavior in mice.Nature communications · 2022Article
- Control of Mammalian Locomotion by Somatosensory Feedback.Comprehensive Physiology · 2021Article
- Fractionated low-dose exposure to ionizing radiation leads to DNA damage, epigenetic dysregulation, and behavioral impairment.Environmental epigenetics · 2016Article
- The Periaqueductal Gray Orchestrates Sensory and Motor Circuits at Multiple Levels of the Neuraxis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Cutaneous reflex modulation and self-induced reflex attenuation in cerebellar patients.Journal of neurophysiology · 2015Article
- Neural substrates underlying fear-evoked freezing: the periaqueductal grey-cerebellar link.The Journal of physiology · 2014Article
- What we do not know about cerebellar systems neuroscience.Frontiers in systems neuroscience · 2014Review
- Collateralization of cerebellar output to functionally distinct brainstem areas. A retrograde, non-fluorescent tracing study in the rat.Frontiers in systems neuroscience · 2014Article
- An adaptive filter model of cerebellar zone C3 as a basis for safe limb control?The Journal of physiology · 2013Review
- Progressive limb ataxia following inferior olive lesions.The Journal of physiology · 2013Article
- Structural basis of cerebellar microcircuits in the rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Establishment of topographic circuit zones in the cerebellum of scrambler mutant mice.Frontiers in neural circuits · 2013Article
- Organization of cerebral projections to identified cerebellar zones in the posterior cerebellum of the rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Architecture and development of olivocerebellar circuit topography.Frontiers in neural circuits · 2012Article
- Behavioural significance of cerebellar modules.Cerebellum (London, England) · 2011Review
- Ins and outs of cerebellar modules.Cerebellum (London, England) · 2011Article
- Cerebellar modules: individual or composite entities?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The cerebellum is divided into multiple parasagittally organized modules, which are thought to represent functional entities. How individual modules participate in cerebellar control of complex movements such as locomotion remains largely unknown. To a large extent, this is caused by the inability to study the contribution of individual modules during locomotion. Because of the architecture of modules, based on narrow, elongated cortical strips that may be discontinuous in the rostrocaudal direction, lesion of a complete module, without affecting neighboring modules, has not been possible. Here, we report on a new method for inducing a selective dysfunction of spatially separated parts of a single module using a small cortical injection of a retrogradely transported neurotoxin, cholera toxin b-subunit-saporin. We show that such a local injection into the C1 module results in climbing fiber and partial mossy fiber deafferentation of functionally related areas of this module, thereby resulting in a severe impairment of the whole module without affecting neighboring modules. A subsequent functional analysis indicates that such an impairment of the hindlimb part of the C1 module did not have a significant impact on skilled walking or overall stepping pattern. However, the modulation of cutaneously induced reflexes during stepping was severely diminished. We propose that the C1 module is specifically involved in the adaptive control of reflexes.
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