ArticleProceedings of the National Academy of Sciences of the United States of America2008
Replication timing, chromosomal bands, and isochores.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 74 citations in OpenAlex.
- Review
- Insights into the evolution and regulation of miRNAs from the view of their DNA replication temporal domains.Frontiers in genetics · 2025Article
- Emergence of enhancers at late DNA replicating regions.Nature communications · 2024Article
- Meiosis through three centuries.Chromosoma · 2024Review
- The "Genomic Code": DNA Pervasively Moulds Chromatin Structures Leaving no Room for "Junk".Life (Basel, Switzerland) · 2021Review
- Developmental differences in genome replication program and origin activation.Nucleic acids research · 2020Article
- Kinetics and mechanisms of mitotic inheritance of DNA methylation and their roles in aging-associated methylome deterioration.Cell research · 2020Article
- 90 YEARS OF PROGESTERONE: Molecular mechanisms of progesterone receptor action on the breast cancer genome.Journal of molecular endocrinology · 2020Review
- The Isochores as a Fundamental Level of Genome Structure and Organization: A General Overview.Journal of molecular evolution · 2017Review
- An Isochore Framework Underlies Chromatin Architecture.PloS one · 2017Article
- Genome wide transcriptome profiling reveals differential gene expression in secondary metabolite pathway of Cymbopogon winterianus.Scientific reports · 2016Article
- Segmenting the Human Genome into Isochores.Evolutionary bioinformatics online · 2015Article
- Chromosome Architecture and Genome Organization.PloS one · 2015Article
- Allele-specific genome-wide profiling in human primary erythroblasts reveal replication program organization.PLoS genetics · 2014Article
- Effects of GWAS-associated genetic variants on lncRNAs within IBD and T1D candidate loci.PloS one · 2014Article
- Compositional patterns in the genomes of unicellular eukaryotes.BMC genomics · 2013Article
- Twisted signatures of GC-biased gene conversion embedded in an evolutionary stable karyotype.Molecular biology and evolution · 2013Article
- Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication.Nucleic acids research · 2013Article
- Unraveling cell type-specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs.Nature structural & molecular biology · 2012Article
- Patterns and evolution of nucleotide landscapes in seed plants.The Plant cell · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromosome replication timing is biphasic (early-late) in the cell cycle of vertebrates and of most (possibly all) eukaryotes. In the present work we have compared the extended, detailed replication timing maps that are available, namely those of human chromosomes 6, 11q, and 21q, with chromosomal bands as visualized at low (400 bands), high (850 bands), and highest (3,200 isochores) resolution. We have observed that the replicons located in a given isochore practically always show either all early or all late replication timing and that early-replicating isochores are short and GC-rich and late-replicating isochores are long and GC-poor. In the vast majority of cases, replicons are clustered in isochores, which are themselves most often clustered in early- or late-replication timing zones and may often reach the size of high-resolution bands and, very rarely, even that of low-resolution bands. Finally, we show that our results should be representative for the whole human genome and thus help to predict replication timing zones in all chromosomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.