ArticleDevelopment (Cambridge, England)2008
Evidence that DIF-1 and hyper-osmotic stress activate a Dictyostelium STAT by inhibiting a specific protein tyrosine phosphatase.
Article in Development (Cambridge, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Evolution of oncogenic signatures of mutation hotspots in tyrosine kinases supports the atavistic hypothesis of cancer.Scientific reports · 2018Article
- Eat Prey, Live:Frontiers in immunology · 2017Review
- The Dictyostelium prestalk inducer differentiation-inducing factor-1 (DIF-1) triggers unexpectedly complex global phosphorylation changes.Molecular biology of the cell · 2015Article
- Two Dictyostelium tyrosine kinase-like kinases function in parallel, stress-induced STAT activation pathways.Molecular biology of the cell · 2014Article
- Cell signaling during development of Dictyostelium.Developmental biology · 2014Review
- Identification of the protein kinases Pyk3 and Phg2 as regulators of the STATc-mediated response to hyperosmolarity.PloS one · 2014Article
- Protein tyrosine phosphatases as wardens of STAT signaling.JAK-STAT · 2014Review
- Article
- The arrestin-domain containing protein AdcA is a response element to stress.Cell communication and signaling : CCS · 2013Article
- Modular evolution of phosphorylation-based signalling systems.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Review
- Identification of the kinase that activates a nonmetazoan STAT gives insights into the evolution of phosphotyrosine-SH2 domain signaling.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Perturbations of the actin cytoskeleton activate a Dictyostelium STAT signalling pathway.European journal of cell biology · 2012Article
- Tyrosine phosphorylation-mediated signaling pathways in dictyostelium.Journal of signal transduction · 2011Article
- Two novel Src homology 2 domain proteins interact to regulate dictyostelium gene expression during growth and early development.The Journal of biological chemistry · 2010Article
- Dual regulation of a Dictyostelium STAT by cGMP and Ca2+ signalling.Journal of cell science · 2010Article
- A new Dictyostelium prestalk cell sub-type.Developmental biology · 2010Article
- Forming patterns in development without morphogen gradients: scattered differentiation and sorting out.Cold Spring Harbor perspectives in biology · 2009Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
STATc becomes tyrosine phosphorylated and accumulates in the nucleus when Dictyostelium cells are exposed to the prestalk cell inducer Differentiation inducing factor 1 (DIF-1), or are subjected to hyper-osmotic stress. We show that the protein tyrosine phosphatase PTP3 interacts directly with STATc and that STATc is refractory to activation in PTP3 overexpressing cells. Conversely, overexpression of a dominant inhibitor of PTP3 leads to constitutive tyrosine phosphorylation and ectopic nuclear localisation of STATc. Treatment of cells with DIF-1 or exposure to hyper-osmotic stress induces a decrease in biochemically assayable PTP3 activity and both agents also induce serine-threonine phosphorylation of PTP3. These observations suggest a novel mode of STAT activation, whereby serine-threonine phosphorylation of a cognate protein tyrosine phosphatase results in the inhibition of its activity, shifting the phosphorylation-dephosphorylation equilibrium in favour of phosphorylation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.