ArticleBMC evolutionary biology2008
Identification of multiple independent horizontal gene transfers into poxviruses using a comparative genomics approach.
Article in BMC evolutionary biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Patterns of genomic deletions in monkeypox virus during the 2022 outbreak in the United States.Nature communications · 2025Article
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- Modular Polymerase Synthesis and Internal Protein Domain Swapping via Dual Opposed Frameshifts in the Ebola Virus L Gene.Pathogens (Basel, Switzerland) · 2024Article
- Eptesipox virus-associated lesions in naturally infected big brown bats.Veterinary pathology · 2024Article
- Monkeypox virus genomic accordion strategies.Nature communications · 2024Article
- Molecular Mechanisms of Poxvirus Evolution.mBio · 2023Review
- RNA Viruses Linked to Eukaryotic Hosts in Thawed Permafrost.mSystems · 2022Article
- Article
- Capripoxviruses, leporipoxviruses, and orthopoxviruses: Occurrences of recombination.Frontiers in microbiology · 2022Review
- Engineered Promoter-Switched Viruses Reveal the Role of Poxvirus Maturation Protein A26 as a Negative Regulator of Viral Spread.Journal of virology · 2021Article
- Capripoxvirus Infections in Ruminants: A Review.Microorganisms · 2021Review
- Discovery of a phylogenetically distinct poxvirus in diseased Crocodilurus amazonicus (family Teiidae).Archives of virology · 2021Article
- Virus-Encoded Complement Regulators: Current Status.Viruses · 2021Review
- Crocodilepox Virus Evolutionary Genomics Supports Observed Poxvirus Infection Dynamics on Saltwater Crocodile (Viruses · 2019Article
- Whole Genome Characterization ofViruses · 2018Article
- Article
- Review
- Cowpox virus: What's in a Name?Viruses · 2017Article
- Non-human Primate Schlafen11 Inhibits Production of Both Host and Viral Proteins.PLoS pathogens · 2016Article
- Horizontal gene transfer events reshape the global landscape of arm race between viruses and homo sapiens.Scientific reports · 2016Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPoxviruses are important pathogens of humans, livestock and wild animals. These large dsDNA viruses have a set of core orthologs whose gene order is extremely well conserved throughout poxvirus genera. They also contain many genes with sequence and functional similarity to host genes which were probably acquired by horizontal gene transfer.Although phylogenetic trees can indicate the occurrence of horizontal gene transfer and even uncover multiple events, their use may be hampered by uncertainties in both the topology and the rooting of the tree. We propose to use synteny conservation around the horizontally transferred gene (HTgene) to distinguish between single and multiple events.
resultsHere we devise a method that incorporates comparative genomic information into the investigation of horizontal gene transfer, and we apply this method to poxvirus genomes. We examined the synteny conservation around twenty four pox genes that we identified, or which were reported in the literature, as candidate HTgenes. We found support for multiple independent transfers into poxviruses for five HTgenes. Three of these genes are known to be important for the survival of the virus in or out of the host cell and one of them increases susceptibility to some antiviral drugs.
conclusionIn related genomes conserved synteny information can provide convincing evidence for multiple independent horizontal gene transfer events even in the absence of a robust phylogenetic tree for the HTgene.
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