ArticleProceedings of the National Academy of Sciences of the United States of America2008
Microarray analyses reveal that plant mutagenesis may induce more transcriptomic changes than transgene insertion.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44 citing papers in PubMed, 168 citations in OpenAlex.
- Deciphering the complex molecular architecture of the genetically modified soybean FG72 through paired-end whole genome sequencing.Food chemistry. Molecular sciences · 2025Article
- Maize ZmLAZ1-3 gene negatively regulates drought tolerance in transgenic Arabidopsis.BMC plant biology · 2024Article
- Comparison of the Phenotypic Performance, Molecular Diversity, and Proteomics in Transgenic Rice.Plants (Basel, Switzerland) · 2022Article
- A portable analog front-end system for label-free sensing of proteins using nanowell array impedance sensors.Scientific reports · 2022Article
- RNA Interference-Based Genetic Engineering Maize Resistant toFrontiers in plant science · 2022Article
- Transcriptomic Analysis of Mature Transgenic Poplar Expressing the Transcription FactorFrontiers in bioengineering and biotechnology · 2022Article
- Evaluation on reprogramed biological processes in transgenic maize varieties using transcriptomics and metabolomics.Scientific reports · 2021Article
- Plant breeding involving genetic engineering does not result in unacceptable unintended effects in rice relative to conventional cross-breeding.The Plant journal : for cell and molecular biology · 2020Article
- Sequencing of two transgenic early-flowering poplar lines confirmed vector-free single-locus T-DNA integration.Transgenic research · 2020Article
- CRISPR-Cas9 Editing in Maize: Systematic Evaluation of Off-target Activity and Its Relevance in Crop Improvement.Scientific reports · 2019Article
- The evolving EU regulatory framework for precision breeding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Article
- Familiarity in the Context of Risk Assessment of Transgenic Crops: Focus on Some Countries in the Americas.Frontiers in bioengineering and biotechnology · 2019Article
- Responses of PYR/PYL/RCAR ABA Receptors to Contrasting stresses, Heat and Cold in Arabidopsis.Plant signaling & behavior · 2019Article
- Safety Assessment of Genetically Modified Feed: Is There Any Difference From Food?Frontiers in plant science · 2019Review
- Unintended effects of transgenic rice revealed by transcriptome and metabolism.GM crops & food · 2019Article
- Scientific mistakes from the agri-food biotech critics.Life sciences, society and policy · 2018Article
- Elevated carotenoids in staple crops: The biosynthesis, challenges and measures for target delivery.Journal, genetic engineering & biotechnology · 2018Review
- Comparative analysis of miRNA expression profiles in transgenic and non-transgenic rice using miRNA-Seq.Scientific reports · 2018Article
- Development of a construct-based risk assessment framework for genetic engineered crops.Transgenic research · 2016Review
- Molecular and genetic characterization of barley mutants and genetic mapping of mutant rpr2 required for Rpg1-mediated resistance against stem rust.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Controversy regarding genetically modified (GM) plants and their potential impact on human health contrasts with the tacit acceptance of other plants that were also modified, but not considered as GM products (e.g., varieties raised through conventional breeding such as mutagenesis). What is beyond the phenotype of these improved plants? Should mutagenized plants be treated differently from transgenics? We have evaluated the extent of transcriptome modification occurring during rice improvement through transgenesis versus mutation breeding. We used oligonucleotide microarrays to analyze gene expression in four different pools of four types of rice plants and respective controls: (i) a gamma-irradiated stable mutant, (ii) the M1 generation of a 100-Gy gamma-irradiated plant, (iii) a stable transgenic plant obtained for production of an anticancer antibody, and (iv) the T1 generation of a transgenic plant produced aiming for abiotic stress improvement, and all of the unmodified original genotypes as controls. We found that the improvement of a plant variety through the acquisition of a new desired trait, using either mutagenesis or transgenesis, may cause stress and thus lead to an altered expression of untargeted genes. In all of the cases studied, the observed alteration was more extensive in mutagenized than in transgenic plants. We propose that the safety assessment of improved plant varieties should be carried out on a case-by-case basis and not simply restricted to foods obtained through genetic engineering.
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