ArticleThe Journal of biological chemistry2008
Molecular and antigenic characterization of a Streptococcus oralis coaggregation receptor polysaccharide by carbohydrate engineering in Streptococcus gordonii.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Leveraging the Capsular Polysaccharide Synthesis Pathway inACS bio & med chem Au · 2025Review
- Identification and genetic engineering of pneumococcal capsule-like polysaccharides in commensal oral streptococci.Microbiology spectrum · 2024Article
- Prospects and Challenges of the Study of Anti-Glycan Antibodies and Microbiota for the Monitoring of Gastrointestinal Cancer.International journal of molecular sciences · 2021Review
- The dental plaque biofilm matrix.Periodontology 2000 · 2021Review
- Diversity and evolution of surface polysaccharide synthesis loci in Enterobacteriales.The ISME journal · 2020Article
- Streptococcus oralis subsp.Infection and immunity · 2019Article
- Diversity-Generating Machines: Genetics of Bacterial Sugar-Coating.Trends in microbiology · 2018Review
- Streptococcus oralis Neuraminidase Modulates Adherence to Multiple Carbohydrates on Platelets.Infection and immunity · 2017Article
- Chemical structures of Streptococcus pneumoniae capsular polysaccharide type 39 (CPS39), CPS47F, and CPS34 characterized by nuclear magnetic resonance spectroscopy and their relation to CPS10A.Journal of bacteriology · 2014Article
- Genetic basis of coaggregation receptor polysaccharide biosynthesis in Streptococcus sanguinis and related species.Molecular oral microbiology · 2014Article
- A phyletically rare gene promotes the niche-specific fitness of an E. coli pathogen during bacteremia.PLoS pathogens · 2013Article
- Article
- Potential nonpneumococcal confounding of PCR-based determination of serotype in carriage.Journal of clinical microbiology · 2012Article
- Structure of type 3Gn coaggregation receptor polysaccharide from Streptococcus cristatus LS4.Carbohydrate research · 2011Article
- Article
- Molecular dissection of the secA2 locus of group B Streptococcus reveals that glycosylation of the Srr1 LPXTG protein is required for full virulence.Journal of bacteriology · 2009Article
- Comparative structural and molecular characterization of ribitol-5-phosphate-containing Streptococcus oralis coaggregation receptor polysaccharides.Journal of bacteriology · 2009Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
The coaggregation receptor polysaccharides (RPS) of Streptococcus oralis and related species are recognized by lectin-like adhesins on other members of the oral biofilm community and by RPS-specific antibodies. The former interactions involve beta-GalNAc or beta-Gal containing host-like motifs in the oligosaccharide repeating units of these polysaccharides, whereas the latter involves features of these molecules that are immunogenic. In the present investigation, the molecular and corresponding structural basis for the serotype specificity of S. oralis ATCC 10557 RPS was determined by engineering the production of this polysaccharide in transformable Streptococcus gordonii 38. This involved the systematic replacement of genes in the rps cluster of strain 38 with different but related genes from S. oralis 10557 and structural characterization of the resulting polysaccharides. The results identify four unique genes in the rps cluster of strain 10557. These include wefI for an alpha-Gal transferase, wefJ for a GalNAc-1-phosphotransferase that has a unique acceptor specificity, wefK for an acetyl transferase that acts at two positions in the hexasaccharide repeating unit, and a novel wzy associated with the beta1-3 linkage between these units. The serotype specificity of engineered polysaccharides correlated with the wefI-dependent presence of alpha-Gal in these molecules rather than with partial O-acetylation or with the linkage between repeating units. The findings illustrate a direct approach for defining the molecular basis of polysaccharide structure and antigenicity.
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