ReviewDrug safety2008
Drug-induced taste disorders.
Review in Drug safety, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Taste disorder's management: a systematic review.Clinical oral investigations · 2020Pooled it
- Trial
- Association between Dysgeusia and Atherosclerotic Cardiovascular Disease: A Cross-Sectional Study With Propensity Score-Matched Analyses.Oral health & preventive dentistry · 2026Article
- Development of Palatable Amorphous Trazodone Hydrochloride Formulations via Ion Exchange.Pharmaceutics · 2025Article
- The Effect of the Number of Adjuvant Chemotherapy Cycles Following Cancer Surgery on Taste Alteration, Energy Intake, and Life Quality: 6-Month Follow-Up Study.Life (Basel, Switzerland) · 2025Article
- Adverse events associated with gepants: a pharmacovigilance analysis based on the FDA adverse event reporting system.The journal of headache and pain · 2025Article
- Assessing Taste and Smell Dysfunction in Acute and Chronic Stroke Patients: Insights From an Adapted Bedside Questionnaire.European journal of neurology · 2025Article
- Investigating the Relationship Between Opium Addiction and Taste Disorder in Addicts Referred to Exir Salamat Addiction Center.Addiction & health · 2025Article
- Automatic detection of fungiform papillae on the human tongue via Convolutional Neural Networks and identification of the best performing model.Computational and structural biotechnology journal · 2025Article
- Taste alterations after hematopoietic cell transplantation: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Assessment of Bitterness in Non-Charged Pharmaceuticals with a Taste Sensor: A Study on Substances with Xanthine Scaffold and Allopurinol.Molecules (Basel, Switzerland) · 2024Article
- Fall risk factors among poly-medicated older Lebanese patients in primary care settings: a secondary cross-sectional analysis of the "MGPIDP-L project".BMC geriatrics · 2024Article
- Delving into the reducing effects of the GABAAlcohol (Fayetteville, N.Y.) · 2023Article
- Endocrinology of Taste with Aging.Endocrinology and metabolism clinics of North America · 2023Review
- Liking of salt is associated with depression, anxiety, and stress.Chemical senses · 2023Article
- Sodium valproate: cacosmia and dysgeusia as uncommon side effects.Archive of clinical cases · 2023Article
- The Influence of Nutritional Status and Sleep Quality on Gustatory Function in Older Adults.Medicina (Kaunas, Lithuania) · 2022Article
- Scoping Review and Evidence Map of the Relation between Exposure to Dietary Sweetness and Body Weight-Related Outcomes in Adults.Advances in nutrition (Bethesda, Md.) · 2022Article
- Assessing physical and chemical properties of saliva among tuberculosis patients on anti-tuberculosis treatment - An observational study.Journal of clinical tuberculosis and other mycobacterial diseases · 2022Article
- Illicit Drug Use and Smell and Taste Dysfunction: A National Health and Nutrition Examination Survey 2013-2014.Healthcare (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Numerous drugs have the potential to adversely influence a patient's sense of taste, either by decreasing function or producing perceptual distortions or phantom tastes. In some cases, such adverse effects are long lasting and cannot be quickly reversed by drug cessation. In a number of cases, taste-related adverse effects significantly alter the patient's quality of life, dietary choices, emotional state and compliance with medication regimens. In this review, we describe common drug-related taste disturbances and review the major classes of medications associated with them, including antihypertensives, antimicrobials and antidepressants. We point out that there is a dearth of scientific information related to this problem, limiting our understanding of the true nature, incidence and prevalence of drug-related chemosensory disturbances. The limited data available suggest that large differences exist among individuals in terms of their susceptibility to taste-related adverse effects, and that sex, age, body mass and genetic variations in taste sensitivity are likely involved. Aside from altering drug usage, management strategies for patients with taste-related adverse effects are sorely needed. Unfortunately, stopping a medication is not always an easy option, particularly when one is dealing with life-threatening conditions such as seizures, cancer, infection, diabetes mellitus and uncontrolled hypertension. Hopefully, the information contained in this review will sensitize physicians, researchers and drug manufacturers to this problem and will result in much more research on this pressing topic.
Indexed as
Identifiers
18302445What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.