Evidence map›Paper›PMID 18302164›Full record

ReviewJournal of cellular physiology2008

Hepatitis B virus-cell interactions and pathogenesis.

David H Nguyen, Laurie Ludgate, Jianming Hu

Abstract readReview
In one paragraph

Review in Journal of cellular physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 92 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

David H NguyenDepartment of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA.
Laurie Ludgate
Jianming Hu
Pennsylvania State University · US

Funding

MECHANISMS OF HEPADNAVIRUS ASSEMBLY AND REPLICATIONR01AI043453 · NIAID · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HU, JIANMING · 1999 to 2017
$5.9M
Mechanisms of Hepadnavirus Assembly and ReplicationR37AI043453 · NIAID · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Jianming Hu · 2018 to 2026
$3.8M
NIAID NIH HHS R01 AI043453NIAID NIH HHS R37 AI043453
6 · The paper itself

Abstract

Like all viruses, hepatitis B virus (HBV) replication and pathogenesis depends on the critical interplay between viral and host factors. In this review, we will focus on the recent progress in understanding the virus-host interactions at the level of the infected cell. These interactions include the requirement of cellular chaperones for the initiation of HBV reverse transcription, the role of the HBV X protein (HBx) in modifying viral and cellular transcription and signaling, the formation of the HBV episomal DNA and its epigenetic regulation in viral persistence, and the cellular factors involved in viral entry, nucleocapsid maturation, and virion secretion.

Indexed as

Virus ReplicationCell CommunicationDNA, CircularDNA, ViralGene Expression Regulation, ViralHepatitis B, ChronicHepatitis B Surface AntigensHepatitis B virusHumansNucleocapsidRNA-Directed DNA PolymeraseTrans-ActivatorsTranscription, GeneticViral Regulatory and Accessory ProteinsDNA, CircularDNA, ViralHepatitis B Surface Antigenshepatitis B virus X proteinRNA-Directed DNA PolymeraseTrans-ActivatorsViral Regulatory and Accessory Proteins

Identifiers

PMID18302164
PMCPMC4386630
OpenAlexW2014475340

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.