ArticlePloS one2008
Relation between the global burden of disease and randomized clinical trials conducted in Latin America published in the five leading medical journals.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Barriers for conducting clinical trials in developing countries- a systematic review.International journal for equity in health · 2018Pooled it
- Medical causes of admissions to hospital among adults in Africa: a systematic review.Global health action · 2013Pooled it
- Characteristics of randomized trials published in Latin America and the Caribbean according to funding source.PloS one · 2013Pooled it
- The IHAT-GUT Iron Supplementation Trial in Rural Gambia: Barriers, Facilitators, and Benefits.Nutrients · 2021Trial
- Awareness, Willingness, and Concerns about Clinical Trial Participation among Iraqi Patients: A Cross-Sectional Study.Global heart · 2026Article
- Mapping the gap: Misalignment between emergency care research and consensus priorities in the Western Cape.Journal of the colleges of medicine of South Africa · 2025Article
- One hundred years of Ecuadorian biomedical scientific output and its association with the main causes of mortality: a bibliometric study.Frontiers in medicine · 2024Article
- Meaningful coproduction with clinicians: establishing a practice-based research network with physiotherapists in regional Australia.Health research policy and systems · 2023Article
- Global Disparities Between Pediatric Publications and Disease Burden From 2006 to 2015.Global pediatric health · 2019Article
- A comparison between health research output and burden of disease in Arab countries: evidence from Palestine.Health research policy and systems · 2018Article
- Spatiotemporal analysis of tropical disease research combining Europe PMC and affiliation mapping web services.Tropical medicine and health · 2017Article
- Automatic classification of registered clinical trials towards the Global Burden of Diseases taxonomy of diseases and injuries.BMC bioinformatics · 2016Article
- Contribution of modifiable risk factors for hypertension and type-2 diabetes in Peruvian resource-limited settings.Journal of epidemiology and community health · 2016Article
- Involvement of low- and middle-income countries in randomized controlled trial publications in oncology.Globalization and health · 2014Article
- Tracking the pharmaceutical pipeline: clinical trials and global disease burden.Clinical and translational science · 2014Article
- Infectious diseases publications in leading medical journals--a comparative analysis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
- Epidemiology in Latin America and the Caribbean: current situation and challenges.International journal of epidemiology · 2012Article
- Article
- Addressing geographical variation in the progression of non-communicable diseases in Peru: the CRONICAS cohort study protocol.BMJ open · 2012Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundSince 1990 non communicable diseases and injuries account for the majority of death and disability-adjusted life years in Latin America. We analyzed the relationship between the global burden of disease and Randomized Clinical Trials (RCTs) conducted in Latin America that were published in the five leading medical journals. METHODOLOGY/PRINCIPAL
findingsWe included all RCTS in humans, exclusively conducted in Latin American countries, and published in any of the following journals: Annals of Internal Medicine, British Medical Journal, Journal of the American Medical Association, Lancet, and New England Journal of Medicine. We described the trials and reported the number of RCTs according to the main categories of the global burden of disease. Sixty-six RCTs were identified. Communicable diseases accounted for 38 (57%) reports. Maternal, perinatal, and nutritional conditions accounted for 19 (29%) trials. Non-communicable diseases represent 48% of the global burden of disease but only 14% of reported trials. No trial addressed injuries despite its 18% contribution to the burden of disease in 2000. CONCLUSIONS/SIGNIFICANCE: A poor correlation between the burden of disease and RCTs publications was found. Non communicable diseases and injuries account for up to two thirds of the burden of disease in Latin America but these topics are seldom addressed in published RCTs in the selected sample of journals. Funding bodies of health research and editors should be aware of the increasing burden of non communicable diseases and injuries occurring in Latin America to ensure that this growing epidemic is not neglected in the research agenda and not affected by publication bias.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.