ArticlePloS one2008
Origin and evolution of GALA-LRR, a new member of the CC-LRR subfamily: from plants to bacteria?
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- The F-box Containing Bacterial Effector RipG6 Destabilizes a Receptor-Like Cytoplasmic Kinase Involved in Plant Immune Signaling.The plant pathology journal · 2026Article
- Sequence features, structure, ligand interaction, and diseases in small leucine rich repeat proteoglycans.Journal of cell communication and signaling · 2021Review
- Shrinking of repeating unit length in leucine-rich repeats from double-stranded DNA viruses.Archives of virology · 2021Article
- Tandem repeats lead to sequence assembly errors and impose multi-level challenges for genome and protein databases.Nucleic acids research · 2019Review
- Prediction of Host-Specific Genes by Pan-Genome Analyses of the KoreanFrontiers in microbiology · 2019Article
- Genome-wide analyses of chitin synthases identify horizontal gene transfers towards bacteria and allow a robust and unifying classification into fungi.BMC evolutionary biology · 2016Article
- Functional assignment to positively selected sites in the core type III effector RipG7 from Ralstonia solanacearum.Molecular plant pathology · 2016Article
- Frameshift Mutation Confers Function as Virulence Factor to Leucine-Rich Repeat Protein fromFrontiers in plant science · 2016Article
- Comparative Geometrical Analysis of Leucine-Rich Repeat Structures in the Nod-Like and Toll-Like Receptors in Vertebrate Innate Immunity.Biomolecules · 2015Review
- Maximum-Likelihood Tree Estimation Using Codon Substitution Models with Multiple Partitions.Molecular biology and evolution · 2015Article
- Darwin and Fisher meet at biotech: on the potential of computational molecular evolution in industry.BMC evolutionary biology · 2015Article
- Article
- Positive selection in the leucine-rich repeat domain of Gro1 genes in Solanum species.Journal of genetics · 2014Article
- Loss and retention of resistance genes in five species of the Brassicaceae family.BMC plant biology · 2014Article
- Repertoire, unified nomenclature and evolution of the Type III effector gene set in the Ralstonia solanacearum species complex.BMC genomics · 2013Article
- Ralstonia solanacearum, a widespread bacterial plant pathogen in the post-genomic era.Molecular plant pathology · 2013Review
- Graph-based modeling of tandem repeats improves global multiple sequence alignment.Nucleic acids research · 2013Article
- CodonPhyML: fast maximum likelihood phylogeny estimation under codon substitution models.Molecular biology and evolution · 2013Article
- Repeat or not repeat?--Statistical validation of tandem repeat prediction in genomic sequences.Nucleic acids research · 2012Article
- Ubiquitination during plant immune signaling.Plant physiology · 2012Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
The phytopathogenic bacterium Ralstonia solanacearum encodes type III effectors, called GALA proteins, which contain F-box and LRR domains. The GALA LRRs do not perfectly fit any of the previously described LRR subfamilies. By applying protein sequence analysis and structural prediction, we clarify this ambiguous case of LRR classification and assign GALA-LRRs to CC-LRR subfamily. We demonstrate that side-by-side packing of LRRs in the 3D structures may control the limits of repeat variability within the LRR subfamilies during evolution. The LRR packing can be used as a criterion, complementing the repeat sequences, to classify newly identified LRR domains. Our phylogenetic analysis of F-box domains proposes the lateral gene transfer of bacterial GALA proteins from host plants. We also present an evolutionary scenario which can explain the transformation of the original plant LRRs into slightly different bacterial LRRs. The examination of the selective evolutionary pressure acting on GALA proteins suggests that the convex side of their horse-shoe shaped LRR domains is more prone to positive selection than the concave side, and we therefore hypothesize that the convex surface might be the site of protein binding relevant to the adaptor function of the F-box GALA proteins. This conclusion provides a strong background for further functional studies aimed at determining the role of these type III effectors in the virulence of R. solanacearum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.