ArticlePloS one2008
Multiple dendritic cell populations activate CD4+ T cells after viral stimulation.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 54 citations in OpenAlex.
- Article
- How cell migration helps immune sentinels.Frontiers in cell and developmental biology · 2022Review
- HIV-1 induction of tolerogenic dendritic cells is mediated by cellular interaction with suppressive T cells.Frontiers in immunology · 2022Article
- A Detailed Overview of Immune Escape, Antibody Escape, Partial Vaccine Escape of SARS-CoV-2 and Their Emerging Variants With Escape Mutations.Frontiers in immunology · 2022Review
- Review
- Interferon-λ modulates dendritic cells to facilitate T cell immunity during infection with influenza A virus.Nature immunology · 2019Article
- Dendritic Cells in the Cross Hair for the Generation of Tailored Vaccines.Frontiers in immunology · 2018Review
- The Biology and Underlying Mechanisms of Cross-Presentation of Exogenous Antigens on MHC-I Molecules.Annual review of immunology · 2017Review
- Cell-to-cell transfer of M. tuberculosis antigens optimizes CD4 T cell priming.Cell host & microbe · 2014Article
- The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells.Nature immunology · 2013Article
- Molecular control of steady-state dendritic cell maturation and immune homeostasis.Annual review of immunology · 2013Review
- Effect of the poly(ethylene glycol) (PEG) density on the access and uptake of particles by antigen-presenting cells (APCs) after subcutaneous administration.Molecular pharmaceutics · 2012Article
- Dendritic cells and influenza A virus infection.Virulence · 2012Review
- Abortive replication of influenza virus in mouse dendritic cells.Journal of virology · 2012Article
- Transcriptional programming of the dendritic cell network.Nature reviews. Immunology · 2012Review
- Transcriptional regulation of dendritic cell diversity.Frontiers in immunology · 2012Article
- Capacities of migrating CD1b+ lymph dendritic cells to present Salmonella antigens to naive T cells.PloS one · 2012Article
- Id2 expression delineates differential checkpoints in the genetic program of CD8α+ and CD103+ dendritic cell lineages.The EMBO journal · 2011Article
- CCR2-antagonist prophylaxis reduces pulmonary immune pathology and markedly improves survival during influenza infection.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Lymphoid organ-resident dendritic cells exhibit unique transcriptional fingerprints based on subset and site.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Dendritic cells (DC) are a heterogeneous cell population that bridge the innate and adaptive immune systems. CD8alpha DC play a prominent, and sometimes exclusive, role in driving amplification of CD8(+) T cells during a viral infection. Whether this reliance on a single subset of DC also applies for CD4(+) T cell activation is unknown. We used a direct ex vivo antigen presentation assay to probe the capacity of flow cytometrically purified DC populations to drive amplification of CD4(+) and CD8(+) T cells following infection with influenza virus by different routes. This study examined the contributions of non-CD8alpha DC populations in the amplification of CD8(+) and CD4(+) T cells in cutaneous and systemic influenza viral infections. We confirmed that in vivo, effective immune responses for CD8(+) T cells are dominated by presentation of antigen by CD8alpha DC but can involve non-CD8alpha DC. In contrast, CD4(+) T cell responses relied more heavily on the contributions of dermal DC migrating from peripheral lymphoid tissues following cutaneous infection, and CD4 DC in the spleen after systemic infection. CD4(+) T cell priming by DC subsets that is dependent upon the route of administration raises the possibility that vaccination approaches could be tailored to prime helper T cell immunity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.