ArticleJournal of materials science. Materials in medicine2008
In vivo behaviour of two different biphasic ceramic implanted in mandibular bone of dogs.
Article in Journal of materials science. Materials in medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Development of a biodegradable α-TCP/PLA/nMgO composite for enhanced guided bone regeneration.Scientific reports · 2025Article
- Maxillary Sinus Augmentation Using Ceramic Alloplastic Granules or Paste: An Experimental Study in Rabbits.Dentistry journal · 2021Article
- [Advances in the Application of Hydroxyapatite Composite Materials in Bone Tissue Engineering].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2021Review
- Article
- Allogenic vs. synthetic granules for bone tissue engineering: an in vitro study.Progress in biomaterials · 2018Article
- Guangxi cobra venom-derived NGF promotes the osteogenic and therapeutic effects of porous BCP ceramic.Experimental & molecular medicine · 2017Article
- Osteogenic Differentiation of MSC through Calcium Signaling Activation: Transcriptomics and Functional Analysis.PloS one · 2016Article
- Human periosteum cell osteogenic differentiation enhanced by ionic silicon release from porous amorphous silica fibrous scaffolds.Journal of biomedical materials research. Part A · 2015Article
- Current application of β-tricalcium phosphate composites in orthopaedics.Orthopaedic surgery · 2012Review
- The association of human primary bone cells with biphasic calcium phosphate (βTCP/HA 70:30) granules increases bone repair.Journal of materials science. Materials in medicine · 2012Article
- Assay of in vitro osteoclast activity on dentine, and synthetic calcium phosphate bone substitutes.Journal of materials science. Materials in medicine · 2012Article
- Bone formation with two types of grafting materials: a histologic and histomorphometric study.The open dentistry journal · 2011Article
- COMPARATIVE STUDY OF BONE NEOFORMATION USING AUTOLOGOUS GRAFTING AND THREE REPLACEMENTS: BONE DEFECTS IN RATS.Revista brasileira de ortopedia · 2009Article
- Periodontal regeneration in experimentally-induced alveolar bone dehiscence by an improved porous biphasic calcium phosphate ceramic in beagle dogs.Journal of materials science. Materials in medicine · 2008Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alloplastic calcium phosphate bone substitutes such as hydroxyapatite (HA) and tricalcium phosphate (TCP) have been studied extensively due to their composition closely resembling the inorganic phase of bone tissue. On the same way, by manipulating the HA/TCP ratio it may be possible to change the substitution rate and the bioactivity of these materials, an advantage which has brought them to clinical use in oral and orthopaedic surgery. In this work, we evaluated the histological response in bone of two biphasic calcium phosphate ceramics by varying the proportion of their components. All premolars of 6 beagle dogs were removed from both sides of the mandible. Three months later, four cylinders composed of 85% HA and 15% beta-TCP (BCP 1) were implanted in the right side of mandible and other four cylinders composed of 15% HA and 85% beta-TCP (BCP 2) were implanted in the left side of mandible of dogs for 4, 12 ad 26 weeks, respectively. Two dogs were used in each time point. The histological study indicated that both biphasic ceramic were biocompatible. The earlier and more quantity of bone formed in BCP 2 than in BCP 1 suggested that the first one had a higher osteoinductive potential than the second one in mandibular bone. The resorption of the phosphate phase and the subsequent migration of bone into the resorbed portions were detected in both biphasic ceramics although two processes appeared faster in BCP 2 than in BCP 1. These dates conclude that varying the components of our biphasic ceramic we improve its osteoinductive potential.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.