ReviewEuropean journal of nuclear medicine and molecular imaging2008
A new integrative model of cerebral activation, deactivation and default mode function in Alzheimer's disease.
Review in European journal of nuclear medicine and molecular imaging, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Translation of task-evoked negative BOLD response into aging and Alzheimer's disease: a systematic review of the current literature.Journal of translational medicine · 2025Pooled it
- Trial
- Using spatial multiple regression to identify intrinsic connectivity networks involved in working memory performance.Human brain mapping · 2012Trial
- Monoclonal antibodies and aptamers: The future therapeutics for Alzheimer's disease.Acta pharmaceutica Sinica. B · 2024Review
- Altered Default Mode Network Is Associated With Cognitive Impairment in CADASIL as Revealed by Multimodal NeuFrontiers in neurology · 2021Article
- Alterations to task positive and task negative networks during executive functioning in Mild Cognitive Impairment.NeuroImage. Clinical · 2018Article
- Disrupted Thalamus White Matter Anatomy and Posterior Default Mode Network Effective Connectivity in Amnestic Mild Cognitive Impairment.Frontiers in aging neuroscience · 2017Article
- Article
- Longitudinal gray-matter volume change in the default-mode network: utility of volume standardized with global gray-matter volume for Alzheimer's disease: a preliminary study.Radiological physics and technology · 2015Article
- Disruption of resting functional connectivity in Alzheimer's patients and at-risk subjects.Current neurology and neuroscience reports · 2014Review
- Consolidation in older adults depends upon competition between resting-state networks.Frontiers in aging neuroscience · 2014Article
- Neurovascular function in Alzheimer's disease patients and experimental models.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2011Review
- [Cognitive reserve and its relevance for the prevention and diagnosis of dementia].Der Nervenarzt · 2011Review
- The default mode network in healthy aging and Alzheimer's disease.International journal of Alzheimer's disease · 2011Article
- Multimodal Imaging of Alzheimer Pathophysiology in the Brain's Default Mode Network.International journal of Alzheimer's disease · 2011Article
- The influence of rest period instructions on the default mode network.Frontiers in human neuroscience · 2010Article
- Alzheimer's disease biomarker discovery in symptomatic and asymptomatic patients: experimental approaches and future clinical applications.Experimental gerontology · 2010Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional imaging methods such as positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) allow in vivo assessment of cerebral metabolism at rest and cerebral responses to cognitive stimuli. Activation studies with different cognitive tasks have deepened the understanding of underlying pathology leading to Alzheimer disease (AD) and how the brain reacts to and potentially compensates the imposed damage inflicted by this disease. The aim of this manuscript study was to summarize current findings of activation studies in healthy people at risk for AD, in people with mild cognitive impairment (MCI) as a possible progenitor of AD and finally in patients with manifest AD, adding recent results about impaired deactivation abilities and default mode function in AD. A new comprehensive model will be introduced integrating these heterogeneous findings and explaining their impact on cognitive performance.
Indexed as
Identifiers
18299829What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.