ReviewThe Analyst2008
Detection of calcium phosphate crystals in the joint fluid of patients with osteoarthritis - analytical approaches and challenges.
Review in The Analyst, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 99 citations in OpenAlex.
- Characterizing Meniscal Calcifications with Photon Counting-Based Dual-Energy Computed Tomography.Annals of biomedical engineering · 2026Article
- TGF-β Enhances Phosphate-Driven Calcification of Human OA Articular Chondrocytes.Calcified tissue international · 2025Article
- An Update on the Diagnosis and Management of Calcium Crystal Disease.Current rheumatology reports · 2023Review
- Oxalate Homeostasis in Non-Stone-Forming Chronic Kidney Disease: A Review of Key Findings and Perspectives.Biomedicines · 2023Review
- Inorganic pyrophosphate is reduced in patients with systemic sclerosis.Rheumatology (Oxford, England) · 2022Article
- Carpal Tunnel Syndrome and Calcium Deposit in the Surgically Transacted Transverse Carpal Ligament.TheScientificWorldJournal · 2022Article
- "Lessons from Rare Forms of Osteoarthritis".Calcified tissue international · 2021Review
- Synovial fluid analysis for the enhanced clinical diagnosis of crystal arthropathies in a tertiary care institution.Clinical rheumatology · 2021Article
- Biofabrication of 3D printed hydroxyapatite composite scaffolds for bone regeneration.Biomedical materials (Bristol, England) · 2021Article
- Benign zinc oxide betaine-modified biochar nanocomposites for phosphate removal from aqueous solutions.Journal of environmental management · 2020Article
- Response to "Letter to the editor: Labral calcification plays a key role in hip pain and symptoms in femoroacetabular impingement".Journal of orthopaedic surgery and research · 2020Article
- Fluorescence Differentiation of ATP-related Multiple Enzymatic Activities in Synovial Fluid as a Marker of Calcium Pyrophosphate Deposition Disease using Kyoto Green.Molecules (Basel, Switzerland) · 2020Article
- Matting Calcium Crystals by Melamine Improves Stabilization and Prevents Dissolution.Crystal growth & design · 2019Article
- Diagnostic advances in synovial fluid analysis and radiographic identification for crystalline arthritis.Current opinion in rheumatology · 2019Review
- Review
- Basic calcium phosphate and pyrophosphate crystals in early and late osteoarthritis: relationship with clinical indices and inflammation.Clinical rheumatology · 2018Article
- Calcium-Containing Crystals and Osteoarthritis: an Unhealthy Alliance.Current rheumatology reports · 2018Review
- Comparison of Meniscal Cell-Mediated and Chondrocyte-Mediated Calcification.The open orthopaedics journal · 2017Article
- A Point-of-Care Raman Spectroscopy-Based Device for the Diagnosis of Gout and Pseudogout: Comparison With the Clinical Standard Microscopy.Arthritis & rheumatology (Hoboken, N.J.) · 2016Article
- Raman spectroscopy detection of molecular changes associated with two experimental models of osteoarthritis in rats.Lasers in medical science · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Clinically, osteoarthritis (OA) is characterised by joint pain, stiffness after immobility, limitation of movement and, in many cases, the presence of basic calcium phosphate (BCP) crystals in the joint fluid. The detection of BCP crystals in the synovial fluid of patients with OA is fraught with challenges due to the submicroscopic size of BCP, the complex nature of the matrix in which they are found and the fact that other crystals can co-exist with them in cases of mixed pathology. Routine analysis of joint crystals still relies almost exclusively on the use of optical microscopy, which has limited applicability for BCP crystal identification due to limited resolution and the inherent subjectivity of the technique. The purpose of this Critical Review is to present an overview of some of the main analytical tools employed in the detection of BCP to date and the potential of emerging technologies such as atomic force microscopy (AFM) and Raman microspectroscopy for this purpose.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.