ArticleProceedings of the National Academy of Sciences of the United States of America2008
Whole-genome analysis reveals molecular innovations and evolutionary transitions in chromalveolate species.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 60 citations in OpenAlex.
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- Genome Analyses of the Microalga Picochlorum Provide Insights into the Evolution of Thermotolerance in the Green Lineage.Genome biology and evolution · 2018Article
- The Apicomplexa-specific glucosamine-6-phosphate N-acetyltransferase gene family encodes a key enzyme for glycoconjugate synthesis with potential as therapeutic target.Scientific reports · 2018Article
- The genome of the protozoan parasite Cystoisospora suis and a reverse vaccinology approach to identify vaccine candidates.International journal for parasitology · 2017Article
- Prokaryotic ancestry and gene fusion of a dual localized peroxiredoxin in malaria parasites.Microbial cell (Graz, Austria) · 2015Article
- The secreted proteins of Achlya hypogyna and Thraustotheca clavata identify the ancestral oomycete secretome and reveal gene acquisitions by horizontal gene transfer.Genome biology and evolution · 2014Article
- Dynamics and innovations within oomycete genomes: insights into biology, pathology, and evolution.Eukaryotic cell · 2012Review
- Biochemical diversification through foreign gene expression in bdelloid rotifers.PLoS genetics · 2012Article
- Reconstruction of oomycete genome evolution identifies differences in evolutionary trajectories leading to present-day large gene families.Genome biology and evolution · 2012Article
- De novo sequence assembly of Albugo candida reveals a small genome relative to other biotrophic oomycetes.BMC genomics · 2011Article
- The search for the missing link: a relic plastid in Perkinsus?International journal for parasitology · 2011Review
- A domain-centric analysis of oomycete plant pathogen genomes reveals unique protein organization.Plant physiology · 2011Article
- Red and problematic green phylogenetic signals among thousands of nuclear genes from the photosynthetic and apicomplexa-related Chromera velia.Genome biology and evolution · 2011Article
- ParameciumDB in 2011: new tools and new data for functional and comparative genomics of the model ciliate Paramecium tetraurelia.Nucleic acids research · 2011Article
- The potential for pathogenicity was present in the ancestor of the Ascomycete subphylum Pezizomycotina.BMC evolutionary biology · 2010Article
- Gene expression in a paleopolyploid: a transcriptome resource for the ciliate Paramecium tetraurelia.BMC genomics · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The chromalveolates form a highly diverse and fascinating assemblage of organisms, ranging from obligatory parasites such as Plasmodium to free-living ciliates and algae such as kelps, diatoms, and dinoflagellates. Many of the species in this monophyletic grouping are of major medical, ecological, and economical importance. Nevertheless, their genome evolution is much less well studied than that of higher plants, animals, or fungi. In the current study, we have analyzed and compared 12 chromalveolate species for which whole-sequence information is available and provide a detailed picture on gene loss and gene gain in the different lineages. As expected, many gene loss and gain events can be directly correlated with the lifestyle and specific adaptations of the organisms studied. For instance, in the obligate intracellular Apicomplexa we observed massive loss of genes that play a role in general basic processes such as amino acid, carbohydrate, and lipid metabolism, reflecting the transition of a free-living to an obligate intracellular lifestyle. In contrast, many gene families show species-specific expansions, such as those in the plant pathogen oomycete Phytophthora that are involved in degrading the plant cell wall polysaccharides to facilitate the pathogen invasion process. In general, chromalveolates show a tremendous difference in genome structure and evolution and in the number of genes they have lost or gained either through duplication or horizontal gene transfer.
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