ArticleLearning & memory (Cold Spring Harbor, N.Y.)2008
Distinct neural mechanisms mediate olfactory memory formation at different timescales.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 88 citations in OpenAlex.
- Article
- Article
- Structural spine plasticity: Learning and forgetting of odor-specific subnetworks in the olfactory bulb.PLoS computational biology · 2022Article
- Article
- Human hippocampal connectivity is stronger in olfaction than other sensory systems.Progress in neurobiology · 2021Article
- The functional relevance of olfactory marker protein in the vertebrate olfactory system: a never-ending story.Cell and tissue research · 2021Review
- Context-dependent odor learning requires the anterior olfactory nucleus.Behavioral neuroscience · 2020Article
- Top-down inputs drive neuronal network rewiring and context-enhanced sensory processing in olfaction.PLoS computational biology · 2019Article
- Learning-Dependent and -Independent Enhancement of Mitral/Tufted Cell Glomerular Odor Responses Following Olfactory Fear Conditioning in Awake Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Kinase activity in the olfactory bulb is required for odor memory consolidation.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Gonadal hormones, but not sex, affect the acquisition and maintenance of a Go/No-Go odor discrimination task in mice.Hormones and behavior · 2018Article
- Long-term habituation of the C-start escape response in zebrafish larvae.Neurobiology of learning and memory · 2016Article
- The Habituation/Cross-Habituation Test Revisited: Guidance from Sniffing and Video Tracking.Neural plasticity · 2016Article
- Fus1 KO Mouse As a Model of Oxidative Stress-Mediated Sporadic Alzheimer's Disease: Circadian Disruption and Long-Term Spatial and Olfactory Memory Impairments.Frontiers in aging neuroscience · 2016Article
- The endocannabinoid system controls food intake via olfactory processes.Nature neuroscience · 2014Article
- Properties and mechanisms of olfactory learning and memory.Frontiers in behavioral neuroscience · 2014Review
- 17β-estradiol enhances memory duration in the main olfactory bulb in CD-1 mice.Behavioral neuroscience · 2013Article
- Chronic anti-murine Aβ immunization preserves odor guided behaviors in an Alzheimer's β-amyloidosis model.Behavioural brain research · 2013Article
- Assessment of cytotoxicity, fetotoxicity, and teratogenicity of Plathymenia reticulata Benth Barks aqueous extract.BioMed research international · 2013Article
- Roles of GSK3β in odor habituation and spontaneous neural activity of the mouse olfactory bulb.PloS one · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Habituation is one of the oldest forms of learning, broadly expressed across sensory systems and taxa. Here, we demonstrate that olfactory habituation induced at different timescales (comprising different odor exposure and intertrial interval durations) is mediated by different neural mechanisms. First, the persistence of habituation memory is greater when mice are habituated on longer timescales. Second, the specificity of the memory (degree of cross-habituation to similar stimuli) also depends on induction timescale. Third, we demonstrate a pharmacological double dissociation between the glutamatergic mechanisms underlying short- and long-timescale odor habituation. LY341495, a class II/III metabotropic glutamate receptor antagonist, blocked habituation only when the induction timescale was short. Conversely, MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist, prevented habituation only when the timescale was long. Finally, whereas short-timescale odor habituation is mediated within the anterior piriform cortex, infusion of MK-801 into the olfactory bulbs prevented odor habituation only at longer timescales. Thus, we demonstrate two neural mechanisms underlying simple olfactory learning, distinguished by their persistence and specificity, mediated by different olfactory structures and pharmacological effectors, and differentially utilized based solely on the timescale of odor presentation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.